Recent progress in understanding protein and lipid factors affecting hepatic VLDL assembly and secretion

Nutrition & Metabolism

Table 1 Biochemically characterized APOB missense mutations in FHBL

Mutation	Predicted location	Hepatosteatosis	Secretion	Retention	Reference
A31P	β-barrel	yes	<5% normal	Golgi	[50]
G275S	α-helix	yes	60% normal	n.d.	[50]
L324M	α-helix	yes	50% normal	n.d.	[50]
L343V	α-helix	yes	50% normal	ER	[48]
R463W	α-helix	yes	50% normal	ER	[47]
G912D	β-sheet	yes	nearly normal	n.d.	[50]
G945S	β-sheet	yes	50% normal	n.d.	[50]

ISSN: 1743-7075