Figure 3
In vivo reverse cholesterol transport in sedentary (SED) and exercising (RUN) mice. At the end of the 2-week experimental period exercising mice (n = 8) and sedentary controls (n = 6) were injected intraperitoneally with 3H-cholesterol-labeled and acLDL-loaded primary mouse peritoneal macrophages and tracer appearance was followed for 48 h as detailed in materials and methods. (A) Time course of tracer appearance in plasma, (B) tracer recovery within liver at the 48 h time point, (C) tracer level within fecal bile acids (BA) after 48 h, (D) tracer recovery within fecal neutral sterols (NS) after 48 h. Data are expressed as percentage of the injected tracer dose and are given as means ± SD.