Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract

Nutrition & Metabolism

Table 2 Effect of consecutive ingestion of Guava Leaf Tea on serum parameters of carbohydrate metabolism in pre- and mild diabetic patients and diabetic patients with T2DM under anti-diabetic medication

Serum parameter	Pre- and mild diabetic patients ¹⁾			Type 2 diabetic patients ²⁾
	n	Initial week	Week 12	n ³⁾	Initial week	Week 8
FBG (mg/dL)	15	136 ± 22	131 ± 25 ^#1	21	183 ± 71	171 ± 76
111-127 mg/dL	7	118 ± 7	112 ± 6 ^#2
Reduction rate of FBG (%)	15	0	4.3 ± 7.6*
HbA_1c(%)	15	6.1 ± 0.7	6.2 ± 0.8	22	7.4 ± 1.4	7.4 ± 1.3
≧ 6.5%				15	8.1 ± 1.1	7.8 ± 1.1*
Insulin (μU/mL)	15	9.0 ± 3.0	7.0 ± 2.0**	19	28.7 ± 26.3	21.5 ± 18.0
≧ 17 μU/mL				11	43.6 ± 25.5	27.5 ± 19.4*
HOMA-IR	15	3.1 ± 1.3	2.3 ± 1.0**	19	12.2 ± 9.9	10.8 ± 13.0

¹⁾ Guava Leaf Tea (190 ml/bottle) was ingested 3 times/day with each meal for 12 weeks by pre-diabetic and mild type 2 diabetic subjects who were 15 males, over 45 years of age and who had an FBG level of 110 mg/dL or higher and a BMI of >22.0.
²⁾ Guava Leaf Tea (200 ml/bottle) was ingested 3 times/day with every meal for 8 weeks by 22 patients with T2DM who had a blood HbA_1c% of >6.0% before intake. Of these 22 patients, 19 received anti-diabetic medication (insulin, sulfonylurea and/or alpha-GI) throughout the trial. Three patients with hypercholesterolemia were also administered fluvastatin, an inhibitor of HMG-CoA reductase in addition to an anti-diabetic drug throughout the trial.
³⁾ Some data under the no fasting condition are omitted.
Values are expressed as mean ± SD. *: p < 0.05, **: p < 0.01, ^#1: p = 0.07, ^#2: p = 0.06 (Dunnett's multiple paired test). Reproduced from [15, 32] with some modifications.

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