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Table 2 Effect of consecutive ingestion of Guava Leaf Tea on serum parameters of carbohydrate metabolism in pre- and mild diabetic patients and diabetic patients with T2DM under anti-diabetic medication

From: Anti-hyperglycemic and anti-hyperlipidemic effects of guava leaf extract

Serum parameter Pre- and mild diabetic patients 1) Type 2 diabetic patients 2)
  n Initial week Week 12 n 3) Initial week Week 8
FBG (mg/dL) 15 136 ± 22 131 ± 25 #1 21 183 ± 71 171 ± 76
111-127 mg/dL 7 118 ± 7 112 ± 6 #2    
Reduction rate of FBG (%) 15 0 4.3 ± 7.6*    
HbA1c(%) 15 6.1 ± 0.7 6.2 ± 0.8 22 7.4 ± 1.4 7.4 ± 1.3
6.5%     15 8.1 ± 1.1 7.8 ± 1.1*
Insulin (μU/mL) 15 9.0 ± 3.0 7.0 ± 2.0** 19 28.7 ± 26.3 21.5 ± 18.0
17 μU/mL     11 43.6 ± 25.5 27.5 ± 19.4*
HOMA-IR 15 3.1 ± 1.3 2.3 ± 1.0** 19 12.2 ± 9.9 10.8 ± 13.0
  1. 1) Guava Leaf Tea (190 ml/bottle) was ingested 3 times/day with each meal for 12 weeks by pre-diabetic and mild type 2 diabetic subjects who were 15 males, over 45 years of age and who had an FBG level of 110 mg/dL or higher and a BMI of >22.0.
  2. 2) Guava Leaf Tea (200 ml/bottle) was ingested 3 times/day with every meal for 8 weeks by 22 patients with T2DM who had a blood HbA1c% of >6.0% before intake. Of these 22 patients, 19 received anti-diabetic medication (insulin, sulfonylurea and/or alpha-GI) throughout the trial. Three patients with hypercholesterolemia were also administered fluvastatin, an inhibitor of HMG-CoA reductase in addition to an anti-diabetic drug throughout the trial.
  3. 3) Some data under the no fasting condition are omitted.
  4. Values are expressed as mean ± SD. *: p < 0.05, **: p < 0.01, #1: p = 0.07, #2: p = 0.06 (Dunnett's multiple paired test). Reproduced from [15, 32] with some modifications.