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Table 6 Phospholipid and ceramide levels in the food and liver of mice fed the high-fat diet alone (HF) or the high-fat diet supplemented with milk phospholipids in the form of phospholipid-rich dairy milk extract (PLRDME)

From: Hepatic accumulation of intestinal cholesterol is decreased and fecal cholesterol excretion is increased in mice fed a high-fat diet supplemented with milk phospholipids

 

Food Intake

Liver

 

HF

HFPL

difference

HF

HFPL

difference

 

nmol/mouse/day

 

nmol/whole organ

 

Phosphatidylcholine

279

11382

+3980%

7568 ± 620

5947 ± 412 *

-21%

Phosphatidylethanolamine

270

12963

+4701%

2022 ± 152

1814 ± 99

-10%

Phosphatidylinositol

72

3242

+4403%

1211 ± 95

1019 ± 68

-16%

Phosphatidylserine

136

5002

+3613%

141 ± 10

129 ± 6

-8%

Lysophosphatidylcholine

662

1048

+58%

274 ± 92

222 ± 28

-19%

Sphingomyelin

245

9670

+3847%

739 ± 71

622 ± 20

-16%

Ceramide

41

87

+112%

75 ± 7

58 ± 4

-22%

Monohexosylceramide

29

858

+857%

24 ± 2

16 ± 1 **

-33%

Dihexosylceramide

45

1295

+1294%

2.7 ± 0.2

2.4 ± 0.2

-11%

Trihexosylceramide

5

6

+20%

nd

nd

nd

  1. Food intake data represent averages of duplicate measurements. Liver lipid results represent means ± SEM for 8 mice in each group. Percentage difference between groups is given in italics. Significant difference between HF and HFPL by Student's t-test: * P < 0.05, ** P < 0.01, *** P < 0.001.