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Table 2 Demographic and metabolic parameters of study population according to FEN1 -10154G>T, FADS2 rs174575, FADS2 rs2727270 and FADS 3 rs1000778C>T

From: Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

 

FEN1-10154G>T

FADS2 rs174575

FADS2 rs2727270

FEN1-10154G>T

 

GG (n = 259)

GT+TT (n = 308)

CC (n = 471)

CG+GG (n = 96)

CC (n = 323)

CT+TT (n = 244)

GG (n = 259)

GT+TT (n = 308)

Age (year)

48.6 ± 9.8

48.7 ± 9.0

48.9 ± 9.4

47.7 ± 9.0

48.4 ± 9.6

49.0 ± 9.0

49.1 ± 9.6

48.3 ± 9.1

BMI (kg/m2)

24.4 ± 2.9

24.4 ± 2.5

24.3 ± 2.7

24.8 ± 2.6

24.4 ± 2.8

24.4 ± 2.5

24.3 ± 2.6

24.5 ± 2.8

Waist (cm)

85.1 ± 6.9

85.9 ± 7.5

85.3 ± 7.3

86.8 ± 7.2

85.1 ± 7.0

86.0 ± 7.5

85.4 ± 7.3

85.6 ± 7.3

Current smokers (%)

34.7

39.0

38.0

32.3

35.3

39.3

35.7

38.3

Current drinkers (%)

83.4

84.4

83.4

86.5

84.8

82.8

79.6

88.2

Sysptolic BP (mmHg)

123.0 ± 14.7

123.2 ± 14.0

122.9 ± 14.3

124.0 ± 14.3

123.1 ± 14.7

123.2 ± 13.8

123.1 ± 13.7

123.1 ± 14.8

Diastolic BP (mmHg)

76.4 ± 11.1

77.3 ± 10.9

76.8 ± 10.9

77.4 ± 11.6

76.3 ± 11.1

77.6 ± 10.9

76.9 ± 10.5

76.9 ± 11.4

TG (mg/dL)§

137.9 ± 76.2

132.1 ± 71.6

133.1 ± 73.7

143.1 ± 73.8

136.7 ± 75.2

132.2 ± 71.9

135.5 ± 80.7

134.1 ± 66.5

Total-C (mg/dL)§

194.5 ± 32.5

190.3 ± 33.8

192.4 ± 33.3

191.4 ± 33.2

194.4 ± 33.4

189.3 ± 33.0

192.5 ± 32.3

192.0 ± 34.2

HDL-C (mg/dL)§

50.0 ± 12.3

50.7 ± 13.7

50.4 ± 13.3

50.2 ± 12.1

50.5 ± 12.3

50.3 ± 14.0

49.6 ± 12.9

51.1 ± 13.2

LDL-C (mg/dL)

117.2 ± 31.4

113.4 ± 31.6

115.6 ± 31.8

112.6 ± 30.3

116.8 ± 32.1

112.9 ± 30.8

116.2 ± 31.3

114.0 ± 31.8

non-HDL-C (mg/dL)

144.5 ± 33.1

139.6 ± 34.5

142.0 ± 34.2

141.2 ± 32.6

143.9 ± 33.8

139.1 ± 34.0

142.8 ± 33.7

140.8 ± 34.2

ApoA1 (mg/dL)

139.9 ± 23.0

141.0 ± 26.1

140.4 ± 24.0

140.9 ± 28.6

141.9 ± 24.5

138.9 ± 24.8

140.8 ± 26.7

140.2 ± 22.7

ApoB (mg/dL)§

88.6 ± 22.3

85.9 ± 24.6

87.0 ± 24.0

87.8 ± 21.3

88.6 ± 22.9

85.4 ± 24.3

85.4 ± 22.9

88.7 ± 24.1

Glucose (mg/dL)

93.3 ± 11.1

92.5 ± 10.4

92.7 ± 10.9

93.9 ± 9.8

93.4 ± 10.7

92.2 ± 10.8

92.3 ± 10.6

93.4 ± 10.9

  1. Means ± S.D. or %, §Tested by log-transformed, Performed by independent t-test or qui-square test, *P < 0.05, **P < 0.01 and ***P < 0.001 compared with major allele for each genotype.
  2. BMI: body mass index, BP: blood pressure, TG: triglyceride, C: cholesterol, Apo: apolipoprotein, HOMA-IR(homeostatis model assessment-insulin resistance): {fasting insulin (μIU/ml) × fasting glucose (mmol/l)}/22.5.