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Table 2 Demographic and metabolic parameters of study population according to FEN1 -10154G>T, FADS2 rs174575, FADS2 rs2727270 and FADS 3 rs1000778C>T

From: Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

  FEN1-10154G>T FADS2 rs174575 FADS2 rs2727270 FEN1-10154G>T
  GG (n = 259) GT+TT (n = 308) CC (n = 471) CG+GG (n = 96) CC (n = 323) CT+TT (n = 244) GG (n = 259) GT+TT (n = 308)
Age (year) 48.6 ± 9.8 48.7 ± 9.0 48.9 ± 9.4 47.7 ± 9.0 48.4 ± 9.6 49.0 ± 9.0 49.1 ± 9.6 48.3 ± 9.1
BMI (kg/m2) 24.4 ± 2.9 24.4 ± 2.5 24.3 ± 2.7 24.8 ± 2.6 24.4 ± 2.8 24.4 ± 2.5 24.3 ± 2.6 24.5 ± 2.8
Waist (cm) 85.1 ± 6.9 85.9 ± 7.5 85.3 ± 7.3 86.8 ± 7.2 85.1 ± 7.0 86.0 ± 7.5 85.4 ± 7.3 85.6 ± 7.3
Current smokers (%) 34.7 39.0 38.0 32.3 35.3 39.3 35.7 38.3
Current drinkers (%) 83.4 84.4 83.4 86.5 84.8 82.8 79.6 88.2
Sysptolic BP (mmHg) 123.0 ± 14.7 123.2 ± 14.0 122.9 ± 14.3 124.0 ± 14.3 123.1 ± 14.7 123.2 ± 13.8 123.1 ± 13.7 123.1 ± 14.8
Diastolic BP (mmHg) 76.4 ± 11.1 77.3 ± 10.9 76.8 ± 10.9 77.4 ± 11.6 76.3 ± 11.1 77.6 ± 10.9 76.9 ± 10.5 76.9 ± 11.4
TG (mg/dL)§ 137.9 ± 76.2 132.1 ± 71.6 133.1 ± 73.7 143.1 ± 73.8 136.7 ± 75.2 132.2 ± 71.9 135.5 ± 80.7 134.1 ± 66.5
Total-C (mg/dL)§ 194.5 ± 32.5 190.3 ± 33.8 192.4 ± 33.3 191.4 ± 33.2 194.4 ± 33.4 189.3 ± 33.0 192.5 ± 32.3 192.0 ± 34.2
HDL-C (mg/dL)§ 50.0 ± 12.3 50.7 ± 13.7 50.4 ± 13.3 50.2 ± 12.1 50.5 ± 12.3 50.3 ± 14.0 49.6 ± 12.9 51.1 ± 13.2
LDL-C (mg/dL) 117.2 ± 31.4 113.4 ± 31.6 115.6 ± 31.8 112.6 ± 30.3 116.8 ± 32.1 112.9 ± 30.8 116.2 ± 31.3 114.0 ± 31.8
non-HDL-C (mg/dL) 144.5 ± 33.1 139.6 ± 34.5 142.0 ± 34.2 141.2 ± 32.6 143.9 ± 33.8 139.1 ± 34.0 142.8 ± 33.7 140.8 ± 34.2
ApoA1 (mg/dL) 139.9 ± 23.0 141.0 ± 26.1 140.4 ± 24.0 140.9 ± 28.6 141.9 ± 24.5 138.9 ± 24.8 140.8 ± 26.7 140.2 ± 22.7
ApoB (mg/dL)§ 88.6 ± 22.3 85.9 ± 24.6 87.0 ± 24.0 87.8 ± 21.3 88.6 ± 22.9 85.4 ± 24.3 85.4 ± 22.9 88.7 ± 24.1
Glucose (mg/dL) 93.3 ± 11.1 92.5 ± 10.4 92.7 ± 10.9 93.9 ± 9.8 93.4 ± 10.7 92.2 ± 10.8 92.3 ± 10.6 93.4 ± 10.9
  1. Means ± S.D. or %, §Tested by log-transformed, Performed by independent t-test or qui-square test, *P < 0.05, **P < 0.01 and ***P < 0.001 compared with major allele for each genotype.
  2. BMI: body mass index, BP: blood pressure, TG: triglyceride, C: cholesterol, Apo: apolipoprotein, HOMA-IR(homeostatis model assessment-insulin resistance): {fasting insulin (μIU/ml) × fasting glucose (mmol/l)}/22.5.