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Table 3 Insulin, HOMA-IR and Fatty acid composition (%) in serum phospholipids according to FEN1 -10154G>T, FADS2 rs174575, FADS2 rs2727270 and rsFADS 3 1000778C>T

From: Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study

  FEN1-10154G>T FADS2 rs174575 FADS2 rs2727270 FEN1-10154G>T
  GG (n = 259) T carrier (n = 308) CC (n = 471) G carrier (n = 96) CC (n = 323) T carrier (n = 244) GG (n = 259) GT+TT (n = 308)
Insulin (μIU/mL)§ 9.1 ± 4.2 8.8 ± 4.3 8.7 ± 3.8 9.7 ± 5.9* 9.3 ± 4.8 8.4 ± 3.3* 8.6 ± 3.6 9.2 ± 4.8
HOMA-IR§ 2.11 ± 1.04 2.03 ± 1.12 2.00 ± 0.96 2.28 ± 1.53* 2.17 ± 1.23 1.93 ± 0.83* 1.98 ± 0.91 2.15 ± 1.23
Total SFA 54.724 ± 0.340 53.694 ± 0.339* 54.374 ± 0.265 53.139 ± 0.583 54.487 ± 0.305 53.739 ± 0.389 54.039 ± 5.359 54.288 ± 6.117
   12:0§ 0.367 ± 0.014 0.411 ± 0.016 0.392 ± 0.012 0.386 ± 0.026 0.377 ± 0.013 0.410 ± 0.018 0.394 ± 0.264 0.388 ± 0.247
   14:0§ 0.595 ± 0.017 0.683 ± 0.056 0.650 ± 0.037 0.604 ± 0.031 0.599 ± 0.016 0.700 ± 0.070 0.599 ± 0.254 0.685 ± 1.019
   16:0 32.736 ± 0.325 32.206 ± 0.298 32.509 ± 0.247 32.152 ± 0.474 32.666 ± 0.283 32.161 ± 0.348 32.403 ± 4.945 32.493 ± 5.514
   18:0§ 19.067 ± 0.204 18.487 ± 0.198* 18.886 ± 0.156 18.092 ± 0.348** 18.892 ± 0.186 18.566 ± 0.223 18.676 ± 3.181 18.826 ± 3.604
Total MUFA 11.353 ± 0.134 11.514 ± 0.146 11.352 ± 0.104 11.877 ± 0.297* 11.483 ± 0.134 11.385 ± 0.151 11.574 ± 2.491 11.311 ± 2.282
   16:1§ 0.628 ± 0.028 0.733 ± 0.048 0.650 ± 0.025 0.859 ± 0.117 0.656 ± 0.032 0.724 ± 0.052 0.681 ± 0.721 0.689 ± 0.655
   18:1 ω-9 6.917 ± 0.101 6.996 ± 0.108 6.903 ± 0.077 7.234 ± 0.225 7.002 ± 0.103 6.903 ± 0.108 7.015 ± 1.869 6.905 ± 1.678
   18:1 ω-7 1.729 ± 0.025 1.712 ± 0.027 1.715 ± 0.020 1.744 ± 0.050 1.739 ± 0.024 1.694 ± 0.029 1.755 ± 0.434 1.685 ± 0.445
Total PUFA 23.978 ± 0.377 24.046 ± 0.349 23.863 ± 0.278 24.761 ± 0.648 24.073 ± 0.343 23.939 ± 0.385 24.135 ± 5.709 23.897 ± 6.455
   Total ω-6 FA 19.237 ± 0.297 19.229 ± 0.274 19.082 ± 0.217 19.973 ± 0.528 19.304 ± 0.272 19.138 ± 0.298 19.286 ± 4.365 19.180 ± 5.178
18:2 ω-6 12.062 ± 0.186 12.853 ± 0.181** 12.303 ± 0.139 13.417 ± 0.352** 12.241 ± 0.172 12.824 ± 0.200* 12.394 ± 2.794 12.587 ± 3.410
18:3 ω-6§ 0.218 ± 0.014 0.233 ± 0.014 0.227 ± 0.012 0.225 ± 0.021 0.223 ± 0.013 0.231 ± 0.017 0.228 ± 0.258 0.225 ± 0.228
20:2 ω-6§ 0.856 ± 0.104 0.880 ± 0.102 0.864 ± 0.082 0.898 ± 0.161 0.855 ± 0.094 0.888 ± 0.115 0.855 ± 1.790 0.883 ± 1.686
20:3 ω-6 1.504 ± 0.034 1.405 ± 0.031* 1.440 ± 0.024 1.498 ± 0.063* 1.492 ± 0.032 1.394 ± 0.033* 1.458 ± 0.513 1.442 ± 0.580
20:4 ω-6 5.016 ± 0.112 4.323 ± 0.099*** 4.690 ± 0.084 4.391 ± 0.162 4.907 ± 0.100 4.285 ± 0.111*** 4.806 ± 1.834 4.478 ± 1.748*
22:4 ω-6§ 0.247 ± 0.020 0.217 ± 0.012 0.230 ± 0.012 0.232 ± 0.024 0.243 ± 0.017 0.214 ± 0.012 0.219 ± 0.191 0.242 ± 0.314
22:5 ω-6§ 0.190 ± 0.013 0.198 ± 0.012 0.191 ± 0.010 0.209 ± 0.021 0.198 ± 0.012 0.190 ± 0.014 0.182 ± 0.194 0.206 ± 0.227
   Total ω-3 FA§ 4.741 ± 0.123 4.818 ± 0.123 4.781 ± 0.097 4.789 ± 0.199 4.769 ± 0.110 4.801 ± 0.141 4.849 ± 2.125 4.717 ± 2.031
18:3 ω-3§ 0.135 ± 0.006 0.162 ± 0.025 0.153 ± 0.017 0.134 ± 0.009 0.134 ± 0.005 0.170 ± 0.032 0.135 ± 0.096 0.163 ± 0.460
20:5 ω-3§ 1.158 ± 0.038 1.166 ± 0.042 1.178 ± 0.032 1.085 ± 0.062 1.161 ± 0.034 1.165 ± 0.048 1.197 ± 0.750 1.129 ± 0.602
22:5 ω-3§ 0.515 ± 0.017 0.546 ± 0.021 0.526 ± 0.015 0.558 ± 0.036 0.523 ± 0.016 0.544 ± 0.024 0.539 ± 0.333 0.525 ± 0.312
22:6 ω-3§ 2.833 ± 0.088 2.868 ± 0.083 2.837 ± 0.066 2.925 ± 0.146 2.852 ± 0.079 2.851 ± 0.093 2.897 ± 1.458 2.807 ± 1.404
18:3 ω-6/18:2 ω-6§ 0.019 ± 0.001 0.020 ± 0.002 0.019 ± 0.001 0.018 ± 0.002 0.019 ± 0.001 0.020 ± 0.002 0.019 ± 0.020 0.020 ± 0.028
20:3 ω-6/18:2 ω-6 0.126 ± 0.003 0.112 ± 0.003** 0.120 ± 0.002 0.111 ± 0.004 0.123 ± 0.002 0.113 ± 0.004* 0.119 ± 0.041 0.118 ± 0.059
20:3 ω-6/18:3 ω-6§ 13.066 ± 0.679 11.460 ± 0.541 12.206 ± 0.469 12.134 ± 1.055 12.527 ± 0.585 11.752 ± 0.626 12.487 ± 10.074 11.907 ± 10.327
20:4 ω-6/18:2 ω-6 0.419 ± 0.010 0.339 ± 0.008*** 0.385 ± 0.007 0.327 ± 0.010*** 0.404 ± 0.008 0.338 ± 0.010*** 0.392 ± 0.157 0.359 ± 0.147**
20:4 ω-6/20:3 ω-6§ 3.509 ± 0.102 3.192 ± 0.060** 3.383 ± 0.065 3.112 ± 0.099 3.462 ± 0.085 3.172 ± 0.069** 3.387 ± 1.020 3.288 ± 1.618*
  1. Mean ± S.D.
  2. §Tested by log-transformed, Performed by general linear model analysis (GLM, Post hoc multiple comparison tests) with adjustment for age, body mass index, cigarette smoking, alcohol drinking, blood pressure, triglyceride, total energy intake and expenditure, followed by Bonferroni correction for multiple comparison.
  3. Adjusted P-value: *P < 0.05, **P < 0.01 and ***P < 0.001 compared with major allele for each genotype