Figure 5

Glucose homeostasis. (A) fasted glycemia (mM), (B) glycemia response (mM) after a glucose challenge in n-3/+ mice (closed squares), in n-3/+ FOS mice (closed circles), in n-3/- mice (open squares) and in n-3/- FOS mice (open circles), (C) area under the curve (arbitrary unit): glycemia response after an oral glucose load, (D) insulinemia 15 minutes after an oral glucose load, (E) insulinogenic index 15 minutes after an oral glucose load, (F) homeostasis model assessment of insulin resistance. Data are the mean ± SEM. *: mean values significantly different (P < 0.05, Student's t-test). -3/+: mice fed with a control diet (n = 9), n-3/+ FOS: mice fed a control diet and supplemented with a prebiotic for 24 days (n = 10), n-3/-: mice fed an n-3 PUFA-depleted diet (n = 12), n-3/- FOS: mice fed an n-3 PUFA-depleted diet and supplemented with a prebiotic for 24 days (n = 12). The results have been partly reported in reference 20.