
DU6

DUhTP



Standard chow

n3 HFD

n6 HFD

Standard chow

n3 HFD

n6 HFD


LSM ± SE

LSM ± SE

LSM ± SE

LSM ± SE

LSM ± SE

LSM ± SE

Leptin (ng/ml)

9·8 ± 3·1^{a, A}

27·9 ± 2·6^{b, A}

27·2 ± 5·5^{b, A}

0·8 ± 0·3^{a, B}

2·5 ± 0·6^{b, B}

1·1 ± 0·4^{a, b, B}

Cholesterol (mM)

4·7 ± 0·8

3·5 ± 0·9

5·2 ± 0·8

6·4 ± 0·9^{a}

4·0 ± 0·8^{b}

6·5 ± 0·8^{a}

FFA (mM)

1·2 ± 0·1^{A}

1·2 ± 0·1^{A}

1·4 ± 0·1^{A}

0·8 ± 0·1^{B}

0·5 ± 0·1^{B}

0·8 ± 0·1^{B}

Insulin (ng/ml)

1·38 ± 0·3^{a, b, A}

0·98 ± 0·3^{a}

1·81 ± 0·3^{b, A}

0·23 ± 0·3^{B}

0·21 ± 0·3

0·19 ± 0·3^{B}

Glucose (mM)

8·9 ± 0·8^{a}

11·0 ± 0·8^{b, A}

11·2 ± 0·8^{b, A}

8·9 ± 0·8

8·9 ± 0·8^{B}

7·9 ± 0·8^{B}

 DU6mouse line selected for high body weight; DUhTPmouse line selected for high treadmill performance
 n3 and n6 HFDhigh fat diet enriched with either n3 or n6 polyunsaturated fatty acids
 LSMLeast square means of 710 mice per group, SEStandard error; FFAfree fatty acids;
 a, bsignificant effect of diet at p ≤ 0.05 within the selected line
 A, Bsignificant effect of selection line at p ≤ 0.05 within the feeding group.