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Table 3 Effect of diet on blood parameter of different mice lines

From: Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain different health outcomes

  DU6 DUhTP
  Standard chow n-3 HFD n-6 HFD Standard chow n-3 HFD n-6 HFD
  LSM ± SE LSM ± SE LSM ± SE LSM ± SE LSM ± SE LSM ± SE
Leptin (ng/ml) 9·8 ± 3·1a, A 27·9 ± 2·6b, A 27·2 ± 5·5b, A 0·8 ± 0·3a, B 2·5 ± 0·6b, B 1·1 ± 0·4a, b, B
Cholesterol (mM) 4·7 ± 0·8 3·5 ± 0·9 5·2 ± 0·8 6·4 ± 0·9a 4·0 ± 0·8b 6·5 ± 0·8a
FFA (mM) 1·2 ± 0·1A 1·2 ± 0·1A 1·4 ± 0·1A 0·8 ± 0·1B 0·5 ± 0·1B 0·8 ± 0·1B
Insulin (ng/ml) 1·38 ± 0·3a, b, A 0·98 ± 0·3a 1·81 ± 0·3b, A 0·23 ± 0·3B 0·21 ± 0·3 0·19 ± 0·3B
Glucose (mM) 8·9 ± 0·8a 11·0 ± 0·8b, A 11·2 ± 0·8b, A 8·9 ± 0·8 8·9 ± 0·8B 7·9 ± 0·8B
  1. DU6-mouse line selected for high body weight; DUhTP-mouse line selected for high treadmill performance
  2. n-3 and n-6 HFD-high fat diet enriched with either n-3 or n-6 polyunsaturated fatty acids
  3. LSM-Least square means of 7-10 mice per group, SE-Standard error; FFA-free fatty acids;
  4. a, b-significant effect of diet at p ≤ 0.05 within the selected line
  5. A, B-significant effect of selection line at p ≤ 0.05 within the feeding group.