A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study

Table 2 Effect of exercise alone or together with Acipimox administration on plasma hormones and biochemical parameters.

	0 min	45 min	45 min	90 min	90 min
	Basal	Exercise	Exercise	Post-exercise	Post-exercise
		+ placebo	+ Aci	+ placebo	+ Aci
NPY (pmol/l)
C group (n = 8)	45 ± 2.3	69.7 ± 19.2**	69 ± 9.2**	45.6 ± 6.7	51.5 ± 12
BN group (n = 8)	53 ± 3.0^$	78.3 ± 15.7**^$	111.4 ± 20.6***^$⁺	51.2 ± 8.6	65 ± 10.6^$
GH (mIU/l)
C group (n = 8)	7.1 ± 0,5	11.3 ± 2.2***	40.9 ± 8.7****	0.7 ± 0.2****	21.4 ± 8.1****
BN group (n = 8)	11.2 ± 0.9^$	13.1 ± 4.3***	73.7 ± 23.1****^$	2.01 ± 0.5****^$	28.9 ± 7.5****^$
Leptin (ng/ml)
C group (n = 8)	7.83 ± 1.3	6.52 ± 0.68*	7.73 ± 1.13⁺	6.21 ± 0.75*	7.84 ± 0.94^#
BN group (n = 8)	6.96 ± 1.1^$	6.31 ± 0.83*	6.8 ± 1.38^$⁺	5.93 ± 0.69*	7.98 ± 0.99*^#
Insulin (mIU/l)
C group (n = 8)	4.32 ± 0.98	4.05 ± 0.37	2.66 ± 0.98*⁺	2.33 ± 0.34*	1.9 ± 0.8**
BN group (n = 8)	2.5 ± 0.59^$	2.32 ± 0.71^$	2.0 ± 0.33*	2.01 ± 0.5*	1.03 ± 0.44**^$#
Glucose (mmol/l)
C group (n = 8)	4.72 ± 0.11	4.8 ± 0.26	4.63 ± 0.19	4.59 ± 0.15	4.33 ± 0.23
BN group (n = 8)	4.33 ± 0.13	4.46 ± 0.38	5.03 ± 0.34*⁺	4.07 ± 0.3	4.43 ± 0.26
FFA (mmol/l)
C group (n = 8)	0.86 ± 0.3	1.54 ± 0.13****	0.82 ± 0.05⁺	0.79 ± 0.05	0.25 ± 0.02****^#
BN group (n = 8)	0.79 ± 0.3	1.6 ± 0.28****	0.79 ± 0.14⁺	0.83 ± 0.1	0.26 ± 0.02****^#
Glycerol (μmol/l)
C group (n = 8)	117 ± 33	318 ± 34****	157.8 ± 18.4⁺⁺	85 ± 7.3	44 ± 4.7**^#
BN group (n = 8)	82.2 ± 26^$	256 ± 56****^$	114 ± 13^$+++	74 ± 4.2	57 ± 6.2**^$#

Values are means ± S.E.M. C = controls (n = 8), BN = bulimia nervosa (n = 8), n = the numbers of subjects are in brackets.
* = P < 0.05, ** = P < 0.01, *** = P < 0.001, **** = P < 0.0001 vs. resting (baseline) values
^$ = P < 0.05 BN vs. control subjects (C)
⁺ = P < 0.05 exercise together with Aci administration vs. exercise alone, 45 minutes
^{+ +} = P < 0.01 exercise together with Aci administration vs. exercise alone, 45 minutes
⁺⁺⁺ = P < 0.001 exercise together with Aci administration vs. exercise alone, 45 minutes
^# = P < 0.05 post-exercise recovering phase together with Aci administration vs. post-exercise recovering phase alone, 90 minutes
Effect of 45-min exercise (2 W/kg of lean body mass [LBM]) alone or together with Acipimox (Aci) administration on plasma adipose tissue (AT)-gut-brain peptides, blood glucose, free fatty acids (FFA) and glycerol levels in the controls (C) (n = 8) and bulimia nervosa (BN) patients (n = 8).

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