A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study

Table 3 Effect of exercise alone or together with Acipimox administration on extracellular glycerol in adipose tissue.

	0 min	45 min	45 min	90 min	90 min
	Basal	Exercise	Exercise	Post-exercise	Post-exercise
		+ placebo	+ Aci	+ placebo	+ Aci
Dialysate Glycerol (μmol/l)
C group (n = 8)	41.21 ± 4.43	82.2 ± 11.82****	41.6 ± 4.21⁺⁺	40.5 ± 3.81	33.9 ± 3.16**^#
BN group (n = 8)	36.39 ± 4.15^$	148.6 ± 23.2****^$^$	38.3 ± 5.39⁺⁺⁺⁺	29.0 ± 2.9^$	20.4 ± 3.01**^$#

** = P < 0.01 vs. resting (baseline) values
**** = P < 0.0001 vs. resting (baseline) values
^$ = P < 0.05 BN vs. control subjects (C)
^$$ = P < 0.01 BN vs. control subjects (C)
⁺⁺ = P < 0.01 exercise together with Aci administration vs. exercise alone, 45 minutes
⁺⁺⁺⁺ = P < 0.0001 exercise together with Aci administration vs. exercise alone, 45 minutes
^# = P < 0.05 post-exercise recovering phase together with Aci administration vs. post-exercise recovering phase alone, 90 minutes
Dialysate glycerol concentration in subcutaneous (sc) abdominal adipose tissue (AT) during baseline conditions (microvials with interstitial fluid samples were collected at 45-min intervals), during exercise (at 45-min interval, 2 W/kg of lean body mass [LBM]), and at the last 45-min interval before ending 90-min post-exercise recovering phase alone or together with Acipimox (Aci) administration in the controls (C) (n = 8) and bulimia nervosa patients (BN) (n = 8). Values are means ± S.E.M. n = the number of subjects.

ISSN: 1743-7075