Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats

Table 3 Expression of genes in liver and gastrocnemius muscle ¹

Gene²	Lean Control	Obese Control	HV-HPMC
mRNA/Actin	Liver
PEPCK	1.4 ± 0.3	1.0 ± 0.3	0.7 ± 0.1^#
G6Pase	1.2 ± 0.2^a	2.8 ± 0.4^b	2.0 ± 0.4^ab
SREBP-1c	1.1 ± 0.3	1.5 ± 0.4	1.2 ± 0.2
FAS	1.3 ± 0.3^a	11.9 ± 1.4^b	10.4 ± 0.9^b
CPT-1α	1.3 ± 0.2^a	2.0 ± 0.6^b	2.7 ± 0.3^b*
	Gastrocnemius Muscle
CPT-1β	1.3 ± 0.2^a	3.3 ± 0.6^b	3.3 ± 0.8^b
PGC-1α	1.1 ± 0.2^a	2.1 ± 0.5^b	1.5 ± 0.2^ab
UCP3	1.0 ± 0.2	1.3 ± 0.4	0.8 ± 0.2

¹ Values represent mean ± SEM, n=5-6 for SREBP-1c and 10–12 for all other values. Values within a row that do not share a common superscript are significantly different, p<0.05. #, p=0.062 compared to lean control. *, p=0.061 compared to the obese control.
² Abbreviations are: PEPCK, phosphoenolpyruvate carboxykinase; G6Pase, glucose-6-phosphatase; SREBP-1c, sterol regulatory element-binding protein 1c; CPT-1α, carnitine palmitoyltransferase 1α; FAS, fatty acid synthase; CPT-1β, carnitine palmitoyltransferase 1β; PGC-1α, peroxisome proliferator-activated receptor coactivator 1α; UCP3, uncoupling protein 3;.

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