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Table 3 Expression of genes in liver and gastrocnemius muscle 1

From: Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats

Gene2 Lean Control Obese Control HV-HPMC
mRNA/Actin Liver
PEPCK 1.4 ± 0.3 1.0 ± 0.3 0.7 ± 0.1#
G6Pase 1.2 ± 0.2a 2.8 ± 0.4b 2.0 ± 0.4ab
SREBP-1c 1.1 ± 0.3 1.5 ± 0.4 1.2 ± 0.2
FAS 1.3 ± 0.3a 11.9 ± 1.4b 10.4 ± 0.9b
CPT-1α 1.3 ± 0.2a 2.0 ± 0.6b 2.7 ± 0.3b*
  Gastrocnemius Muscle
CPT-1β 1.3 ± 0.2a 3.3 ± 0.6b 3.3 ± 0.8b
PGC-1α 1.1 ± 0.2a 2.1 ± 0.5b 1.5 ± 0.2ab
UCP3 1.0 ± 0.2 1.3 ± 0.4 0.8 ± 0.2
  1. 1 Values represent mean ± SEM, n=5-6 for SREBP-1c and 10–12 for all other values. Values within a row that do not share a common superscript are significantly different, p<0.05. #, p=0.062 compared to lean control. *, p=0.061 compared to the obese control.
  2. 2 Abbreviations are: PEPCK, phosphoenolpyruvate carboxykinase; G6Pase, glucose-6-phosphatase; SREBP-1c, sterol regulatory element-binding protein 1c; CPT-1α, carnitine palmitoyltransferase 1α; FAS, fatty acid synthase; CPT-1β, carnitine palmitoyltransferase 1β; PGC-1α, peroxisome proliferator-activated receptor coactivator 1α; UCP3, uncoupling protein 3;.