Improved glycemic control in db/db mice after 10 weeks of treatment with EGCG or rosiglitazone. Mice received dietary supplementation with 1% (w/w) EGCG or 0.0021% (w/w) rosiglitazone (Rosi) for 10 weeks. Shown are fasting blood glucose levels (A), fasting plasma insulin levels (B), blood glucose concentrations (C, D) and plasma insulin concentrations (E, F) during an oral glucose tolerance test (OGTT). Raw data from OGTT are presented in C and E while calculated area under the curve is presented in D and F for blood glucose and plasma insulin respectively. Values represent mean ± SEM for 9 mice in each group. * denotes P < 0.05 for a chance difference vs controls using one-way ANOVA in conjunction with Dunnett's multiple comparison test.