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Table 1 Liver gene expression in rats in response to each diet with or without fluvastatin

From: Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet

Gene SD (fold induction) Inulin-supplemented SD (fold induction) HF (fold induction) Inulin-supplemented HF (fold induction)
  Control Fluvastatin Control Fluvastatin Control Fluvastatin Control Fluvastatin
CYP1A1 1.00 ± 0.44 4.31 ± 0.03** 0.86 ± 0.24 3.13 ± 0.99* 0.10 ± 0.02*** 0.24 ± 0.12*** 0.31 ± 0.12*** 0.15 ± 0.06***
CYP1A2 1.00 ± 0.08 1.29 ± 0.06* 1.06 ± 0.09 1.34 ± 0.06* 0.22 ± 0.02*** 0.31 ± 0.02*** 0.52 ± 0.06***,# 0.57 ± 0.03**,#
CYP2B1 1.00 ± 0.28 1.43 ± 0.39 0.89 ± 0.20 0.83 ± 0.03 0.59 ± 0.09 0.68 ± 0.09 0.57 ± 0.15 0.23 ± 0.05*
CYP2C11 1.00 ± 0.04 0.82 ± 0.04 0.81 ± 0.15 0.85 ± 0.08 0.83 ± 0.05 0.76 ± 0.09 0.62 ± 0.15* 0.58 ± 0.03*
CYP2E1 1.00 ± 0.06 1.35 ± 0.12 1.43 ± 0.15** 1.47 ± 0.11* 0.37 ± 0.07** 0.84 ± 0.14# 0.89 ± 0.10# 0.44 ± 0.04*
CYP3A1 1.00 ± 0.09 0.81 ± 0.13 1.06 ± 0.05 0.88 ± 0.08 0.77 ± 0.11 0.91 ± 0.19 0.82 ± 0.07 0.54 ± 0.04*
CYP3A2 1.00 ± 0.09 0.81 ± 0.07 1.20 ± 0.10 0.87 ± 0.07 0.72 ± 0.09 0.78 ± 0.15 0.74 ± 0.05 0.68 ± 0.07*
CYP4A1 1.00 ± 0.06 1.28 ± 0.13 1.76 ± 0.73 1.20 ± 0.10 0.53 ± 0.04 0.64 ± 0.20 1.43 ± 0.28# 1.12 ± 0.17
CYP4A2 1.00 ± 0.14 2.45 ± 0.54* 2.94 ± 0.54* 1.46 ± 0.19 0.42 ± 0.28 0.39 ± 0.27 1.00 ± 0.24 0.34 ± 0.01
CYP4A3 1.00 ± 0.08 1.08 ± 0.14 1.24 ± 0.40 0.80 ± 0.08 0.53 ± 0.03 0.55 ± 0.13 1.33 ± 0.29 1.01 ± 0.08
CPR 1.00 ± 0.09 1.17 ± 0.13 1.17 ± 0.07 1.45 ± 0.12 1.20 ± 0.12 1.03 ± 0.05 1.23 ± 0.15 1.19 ± 0.21
CAR 1.00 ± 0.10 0.74 ± 0.15 1.51 ± 0.20 1.31 ± 0.24 1.44 ± 0.33 1.26 ± 0.36 1.51 ± 0.20 0.47 ± 0.21
PXR 1.00 ± 0.04 0.81 ± 0.06 1.10 ± 0.16 1.08 ± 0.11 0.85 ± 0.10 0.86 ± 0.10 0.93 ± 0.08 0.60 ± 0.05*
RXR 1.00 ± 0.05 0.76 ± 0.03 0.98 ± 0.06 0.88 ± 0.08 1.08 ± 0.04 0.92 ± 0.06 1.13 ± 0.06 1.06 ± 0.26
AhR 1.00 ± 0.20 0.74 ± 0.07 1.09 ± 0.26 1.04 ± 0.16 0.52 ± 0.03* 1.10 ± 0.17 1.02 ± 0.09 0.68 ± 0.13
ARNT 1.00 ± 0.06 0.86 ± 0.05 0.91 ± 0.02 0.81 ± 0.03 0.69 ± 0.09*** 0.76 ± 0.05** 0.80 ± 0.06 0.74 ± 0.04*
  1. *p < 0.05, **p < 0.01, ***p < 0.001 versus SD-fed animals; #p < 0.05 versus HF-fed animals.
  2. Rats were fed the SD-, inulin-supplemented SD-, HF-, or inulin-supplemented HF diets for 1 week, continued to consume each diet containing fluvastatin (0 or 4 mg/kg/day) for another 2 weeks, and then sacrificed. Relative levels were expressed by taking the control values obtained from SD-diet-fed rats as 1.00. Values are the means ± S.E. of 4 determinations in each group.