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Table 1 Liver gene expression in rats in response to each diet with or without fluvastatin

From: Effects of dietary inulin, statin, and their co-treatment on hyperlipidemia, hepatic steatosis and changes in drug-metabolizing enzymes in rats fed a high-fat and high-sucrose diet

Gene

SD (fold induction)

Inulin-supplemented SD (fold induction)

HF (fold induction)

Inulin-supplemented HF (fold induction)

 

Control

Fluvastatin

Control

Fluvastatin

Control

Fluvastatin

Control

Fluvastatin

CYP1A1

1.00 ± 0.44

4.31 ± 0.03**

0.86 ± 0.24

3.13 ± 0.99*

0.10 ± 0.02***

0.24 ± 0.12***

0.31 ± 0.12***

0.15 ± 0.06***

CYP1A2

1.00 ± 0.08

1.29 ± 0.06*

1.06 ± 0.09

1.34 ± 0.06*

0.22 ± 0.02***

0.31 ± 0.02***

0.52 ± 0.06***,#

0.57 ± 0.03**,#

CYP2B1

1.00 ± 0.28

1.43 ± 0.39

0.89 ± 0.20

0.83 ± 0.03

0.59 ± 0.09

0.68 ± 0.09

0.57 ± 0.15

0.23 ± 0.05*

CYP2C11

1.00 ± 0.04

0.82 ± 0.04

0.81 ± 0.15

0.85 ± 0.08

0.83 ± 0.05

0.76 ± 0.09

0.62 ± 0.15*

0.58 ± 0.03*

CYP2E1

1.00 ± 0.06

1.35 ± 0.12

1.43 ± 0.15**

1.47 ± 0.11*

0.37 ± 0.07**

0.84 ± 0.14#

0.89 ± 0.10#

0.44 ± 0.04*

CYP3A1

1.00 ± 0.09

0.81 ± 0.13

1.06 ± 0.05

0.88 ± 0.08

0.77 ± 0.11

0.91 ± 0.19

0.82 ± 0.07

0.54 ± 0.04*

CYP3A2

1.00 ± 0.09

0.81 ± 0.07

1.20 ± 0.10

0.87 ± 0.07

0.72 ± 0.09

0.78 ± 0.15

0.74 ± 0.05

0.68 ± 0.07*

CYP4A1

1.00 ± 0.06

1.28 ± 0.13

1.76 ± 0.73

1.20 ± 0.10

0.53 ± 0.04

0.64 ± 0.20

1.43 ± 0.28#

1.12 ± 0.17

CYP4A2

1.00 ± 0.14

2.45 ± 0.54*

2.94 ± 0.54*

1.46 ± 0.19

0.42 ± 0.28

0.39 ± 0.27

1.00 ± 0.24

0.34 ± 0.01

CYP4A3

1.00 ± 0.08

1.08 ± 0.14

1.24 ± 0.40

0.80 ± 0.08

0.53 ± 0.03

0.55 ± 0.13

1.33 ± 0.29

1.01 ± 0.08

CPR

1.00 ± 0.09

1.17 ± 0.13

1.17 ± 0.07

1.45 ± 0.12

1.20 ± 0.12

1.03 ± 0.05

1.23 ± 0.15

1.19 ± 0.21

CAR

1.00 ± 0.10

0.74 ± 0.15

1.51 ± 0.20

1.31 ± 0.24

1.44 ± 0.33

1.26 ± 0.36

1.51 ± 0.20

0.47 ± 0.21

PXR

1.00 ± 0.04

0.81 ± 0.06

1.10 ± 0.16

1.08 ± 0.11

0.85 ± 0.10

0.86 ± 0.10

0.93 ± 0.08

0.60 ± 0.05*

RXR

1.00 ± 0.05

0.76 ± 0.03

0.98 ± 0.06

0.88 ± 0.08

1.08 ± 0.04

0.92 ± 0.06

1.13 ± 0.06

1.06 ± 0.26

AhR

1.00 ± 0.20

0.74 ± 0.07

1.09 ± 0.26

1.04 ± 0.16

0.52 ± 0.03*

1.10 ± 0.17

1.02 ± 0.09

0.68 ± 0.13

ARNT

1.00 ± 0.06

0.86 ± 0.05

0.91 ± 0.02

0.81 ± 0.03

0.69 ± 0.09***

0.76 ± 0.05**

0.80 ± 0.06

0.74 ± 0.04*

  1. *p < 0.05, **p < 0.01, ***p < 0.001 versus SD-fed animals; #p < 0.05 versus HF-fed animals.
  2. Rats were fed the SD-, inulin-supplemented SD-, HF-, or inulin-supplemented HF diets for 1 week, continued to consume each diet containing fluvastatin (0 or 4 mg/kg/day) for another 2 weeks, and then sacrificed. Relative levels were expressed by taking the control values obtained from SD-diet-fed rats as 1.00. Values are the means ± S.E. of 4 determinations in each group.
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Nutrition & Metabolism

ISSN: 1743-7075

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