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Table 3 AUC GLUCOSE , K ITT and T ½ values during a random-fed insulin tolerance test administered to male and female C57Bl/6 J mice (n = 18 per gender)

From: Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis

  CONTROL MSG ASP MSG + ASP p-value
MEAN SEM MEAN SEM MEAN SEM MEAN SEM
Basal Glucose (mg/dL)          
male 119.36a 2.80 117.92a 4.71 143.72 5.41b 122.64a 2.90 <.0001
female 112.39ab 4.49 108.50a 1.96 120.33ab** 4.94 125.08b 2.30 <.01
AUCGLUCOSE (mg/dL.min)         
male 4829.58a 131.96 5522.29ab 152.69 5829.79bc 197.07 6454.79c 266.98 <.0001
female 4819.93 190.36 4717.92** 76.45 5288.33 217.38 5057.92** 233.79 0.156
K. ITT (%/min)          
male 2.92a 0.28 2.10ab 0.20 2.32a 0.29 1.15b 0.26 0.001
female 2.60 0.37 2.28 0.26 2.40 0.19 1.95* 0.26 0.436
GLUCOSE (min)          
male 39.69a 14.05 37.91a 3.84 51.61ab 16.63 105.56b 23.72 0.022
female 39.02 6.38 41.54 7.66 32.36 2.90 92.55 36.44 0.105
  1. Significant differences between diets are indicated by different letters abc. *, ** indicate differences between males and females within each diet P < 0.05 and 0.01 respectively.
  2. P-values for comparison of diets are calculated using one way ANOVA, dissimilar means are denoted by different letters abc.
  3. *,** indicate p-value of < .05, <.01 when comparing males to females within each diet group.