Interactive effects of neonatal exposure to monosodium glutamate and aspartame on glucose homeostasis

Nutrition & Metabolism

Table 3 AUC _GLUCOSE , K _ITT and T _½ values during a random-fed insulin tolerance test administered to male and female C57Bl/6 J mice (n = 18 per gender)

	CONTROL		MSG		ASP		MSG + ASP		p-value
	MEAN	SEM	MEAN	SEM	MEAN	SEM	MEAN	SEM	p-value
Basal Glucose (mg/dL)
male	119.36^a	2.80	117.92^a	4.71	143.72	5.41^b	122.64^a	2.90	<.0001
female	112.39^ab	4.49	108.50^a	1.96	120.33^ab**	4.94	125.08^b	2.30	<.01
AUC_GLUCOSE (mg/dL.min)
male	4829.58^a	131.96	5522.29^ab	152.69	5829.79^bc	197.07	6454.79^c	266.98	<.0001
female	4819.93	190.36	4717.92**	76.45	5288.33	217.38	5057.92**	233.79	0.156
K. _ITT (%/min)
male	2.92^a	0.28	2.10^ab	0.20	2.32^a	0.29	1.15^b	0.26	0.001
female	2.60	0.37	2.28	0.26	2.40	0.19	1.95*	0.26	0.436
T½_GLUCOSE (min)
male	39.69^a	14.05	37.91^a	3.84	51.61^ab	16.63	105.56^b	23.72	0.022
female	39.02	6.38	41.54	7.66	32.36	2.90	92.55	36.44	0.105

Significant differences between diets are indicated by different letters abc. *, ** indicate differences between males and females within each diet P < 0.05 and 0.01 respectively.
P-values for comparison of diets are calculated using one way ANOVA, dissimilar means are denoted by different letters abc.
*,** indicate p-value of < .05, <.01 when comparing males to females within each diet group.