Figure 1

Regulation of GWAS obesity genes in the hypothalamus in the fed state and by high fat feeding. Open bars represent the chow-fed, fasted controls; red bars represent the chow-fed non-fasted group; and blue bars represent the high fat fed group (fasted prior to tissue collection). The number of mice in the chow fasted, chow fed, and HFD fasted groups were: Bat2 (10, 5, 7), C10orf97 (10, 7, 5), Dgkg (4, 5, 5), Etv5 (10, 7, 7) Faim2 (4, 5, 5), Gnpda2 (9, 9, 6), Kctd15 (7, 5, 6), Maf (7, 7, 7), Mtch2 (10, 9, 7), Negr1 (10, 7, 7), Npc1 (10, 5, 7), Pter (10, 8, 6), Sfrs10 (10, 7, 5) and Sh2b1 (9, 6, 7), respectively. P-values vs. the chow-fed fasted controls: * <0.05, ** <0.01, ^# <0.1.