Figure 5
From: Early nocturnal meal skipping alters the peripheral clock and increases lipogenesis in mice
Circadian alterations in lipogenic genes by ENF under isocaloric conditions. Liver and epididymal fat samples were collected at ZT 0, 4, 8, 12, 16 and 20 after 4 days of treatment. Gene expression of sterol regulatory element binding protein-1c (Srebp-1c), peroxisome proliferator-activated receptor α (Ppar α), fatty acid synthase (Fas), acetyl-CoA carboxylase (Acc), stearoyl-coenzyme A desaturase-1 (Scd-1) and glycerol-phosphate acyl-transferase-1 (Gpat-1) under CR diets (shown in Figure 4) was estimated by RT-PCR under different dietary conditions. The relative levels (IC control = 1) were further normalized to the 18S RNA levels. Dark periods are indicated by the gray area. All of the values are expressed as the mean +/- SEM (n = 6 per time point). *p < 0.05 for the ENF groups compared with the IC-control.