Figure 7
An adipocyte FGFR1-mediated hepatocyte-adipocyte communication axis during hepatic stress. Diverse conditions as the metabolic extremes of starvation, obesity and chemical and biological insults induce FGF21 that signals the stress to adipocytes. FGF21 activates adipose FGFR1 signaling to inhibit adipocyte lipolysis and to activate signals back to the liver that collectively dampen lipogenesis, steatosis and hepatic stress.