Nutrition & Metabolism

Table 2 Effects of ALA on fat depots of WT, AMPKα1 ^−/− and AMPKα2 ^−/− mice fed HFD

From: AMP-activated protein kinase is required for the anti-adipogenic effects of alpha-linolenic acid

	WT		AMPKα1 ^−/−		AMPKα2 ^−/−
	HF	HF-A	HF	HF-A	HF	HF-A
Final BW (g)	42.6 ± 3.1	32.6 ± 1.8^ab	43.1 ± 3.0	42 ± 3.2	45.5 ± 3.4	44.2 ± 3.7
Epididymal
weight (mg)	2270 ± 158	1224 ± 98^ab	2242 ± 201	2137 ± 198	2349 ± 178	2146 ± 184
DNA (μg/mg)	0.32 ± 0.04	0.67 ± 0.05^ab	0.29 ± 0.05	0.35 ± 0.06	0.29 ± 0.05	0.36 ± 0.07
Inguinal
Weight (mg)	1090 ± 42	1037 ± 57	1097 ± 45	1058 ± 55	1102 ± 49	1072 ± 59
DNA (μg/mg)	0.42 ± 0.05	0.5 ± 0.06	0.36 ± 0.04	0.39 ± 0.06	0.38 ± 0.05	0.41 ± 0.07

Note: The values are means ± SE. ^aP < 0.05 for difference between different genotypes with HF-A diet; ^bP < 0.05 for difference between WT mice. BW, body weight. HF, mice fed high-fat diet; HF-A, mice fed high-fat diet with ALA.

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