Nutrition & Metabolism

Table 7 Estimates of D6D activity according to genotype for each FADS2 SNP in Caucasians

From: Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study

	Males							Females
	MM		Mm		mm		p-value	MM		Mm		mm		p-value
		SEM		SEM		SEM			SEM		SEM		SEM
rs174570	2.461	0.118	2.461	0.118	3.865		0.60	3.121^b	0.100	3.546^a,b	0.182	5.180^a	0.612	0.60 × 10⁻²
rs174576	2.340	0.157	2.543	0.168	2.980	1.138	0.52	2.984^b	0.108	3.254^b	0.133	4.388^a	0.334	4.44 × 10⁻⁵*
rs174579	2.437	0.134	2.625	0.203	2.625	0.203	0.43	3.108	0.101	3.551	0.177	3.447	0.445	0.12
rs174593	2.524	0.159	2.516	0.169	2.349	0.276	0.68	3.074	0.101	3.529	0.168	3.343	0.341	0.03
rs174602	2.519	0.154	2.453	0.170	2.698	0.346	0.71	3.149	0.099	3.384	0.168	3.789	0.537	0.15
rs174611	2.52	0.196	2.329	0.153	3.160	0.353	0.07	3.152	0.123	3.484	0.148	2.995	0.231	0.59
rs174626	2.417	0.198	2.512	0.167	2.605	0.215	0.72	3.118	0.169	3.200	0.119	3.564	0.203	0.30
rs174627	2.443	0.129	2.638	0.215	2.859	0.123	0.50	3.245	0.102	3.346	0.192	3.212	0.517	0.90
rs17831757	2.531	0.125	2.352	0.221	3.131	1.429	0.73	3.282	0.105	3.212	0.177	3.332	0.285	0.70
rs2072114	2.460	0.128	2.587	0.215	3.000	1.030	0.91	3.144^b	0.095	3.444^b	0.212	5.370^a	0.460	1.20 × 10⁻³
rs2845573	NA							3.169^b	0.094	3.585^a,b	0.246	5.179^a	0.612	0.03
rs2851682	2.435	0.113	2.708	0.297	4.560		0.15	3.208	0.098	3.354	0.208	5.180	0.612	0.07
rs482548	2.537	0.116	2.345	0.324	2.958		0.90	3.303	0.102	3.142	0.171	2.233	0.206	0.38
rs498793	2.759	0.195	2.305	0.127	2.388	0.259	0.38	3.445	0.168	3.051	0.102	3.665	0.296	0.06
rs526126	2.398	0.117	2.589	0.234	3.528	0.581	0.02	3.250	0.107	3.377	0.182	2.967	0.274	0.43
rs968567	2.457	0.128	2.619	0.214	2.982		0.61	3.162	0.100	3.506	0.185	3.463	0.703	0.32

Results of analysis of 16 SNP from the FADS2 for associations with D6D activity index [DHA/EPA]. Different letters (^a or ^b) denote values that are significantly different between groups. The * denotes p-values which are significant and withstood multiple testing. P-values were determined using multiple linear regression models which were adjusted for BMI, age, dietary LA, ALA, EPA and DHA, % total energy from dietary fat and physical activity. Abbreviations: D6D delat-6-desaturase, M major, m minor, SEM standard error of the mean, NA not applicable.

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