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Fig. 2 | Nutrition & Metabolism

Fig. 2

From: A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes

Fig. 2

Sphaeranthus Indicus extract inhibits TNF-α-induced production of adhesion molecules human umbilical vein endothelial cells. Confluent HUVECs in 96-well fibronectin–coated plates were pretreated with various concentrations of S. indicus or 7-HF for 30 min before being stimulated with 1 ng/mL TNF-α for the indicated time. The expressions of ICAM-1 and E-selectin were evaluated after TNF-α stimulation for 4 h, and expression of VCAM-1 was evaluated after 6 h of stimulation. The 50 % inhibitory concentration (IC50) values were calculated by a nonlinear regression method using GraphPad software

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