Compared to casein, bovine lactoferrin reduces plasma leptin and corticosterone and affects hypothalamic gene expression without altering weight gain or fat mass in high fat diet fed C57/BL6J mice

Table 2 Hypothalamic gene-set analysis comparing the HFD and HFD + Lac groups^a

^a Gene names: Agrp, agouti related protein homolog (mouse); Brs3, bombesin-like receptor 3; Cartpt, CART prepropeptide, Cckar, cholecystokinin A receptor; Cckabr, cholecystokinin B receptor; Fyn, FYN oncogene related to SRC, FGR, YES; Galr2, galanin receptor 2; Gcg, glucagon; Ghrl, ghrelin/obestatin; Ghsr, ghrelin/obestatin prepropeptide; Hcrtr1, hypocretin (orexin) receptor 1; Mc4r, melanocortin 4 receptor; Pmch, pro-melanin-concentrating hormone; Pyy, peptide YY; Ubr3, ubiquitin protein ligase E3 component n-recognin 3; Rdh12, retinol dehydrogenase 12 (all-trans/9-cis/11-cis); Cyp26a1, cytochrome p450, family 26, subfamily A, polypeptide 1; Aldh1a1, aldehyde dehydrogenase 1 family, member A1; Rdh, retinol dehydrogenase 8 (all-trans); Rdh11, retinol dehydrogenase 11 (all-trans/9-cis/11-cis); Retsat, retinol saturase (all-trans-retinol 13, 14-reductase); Cyp26b1, cytochrome p450, family 26, subfamily B, polypeptide 1; Rpe65, retinal pigment epithelium-specific protein 65 kDa; Dgat2, diacylglycerol O-acyltransferase 2; Aldh1a2, Aldehyde dehydrogenase 1 family, member A2; Dhrs3, dehydrogenase/reductase (SDR family) member 3
Abbreviations: NES normalized enrichment score; NOM nominal; FDR false discovery rate

ISSN: 1743-7075