Fig. 5

Chronic low glucose activates 5-HT release through a transcriptional pathway. (a) 24 h in 5 mM glucose causes and increase in Tph1 gene expression (vs 25 mM glucose, N = 3 preparations n = 9 per group. ** p < 0.01). (b) This results in an increase in 5-HT release events measured with amperometry and (c) more 5-HT molecules released during stimulation. n = 30 cells for 25 mM and 7 cells for 5 mM. *p < 0.05