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Fig. 7 | Nutrition & Metabolism

Fig. 7

From: Short chain acyl-CoA dehydrogenase deficiency and short-term high-fat diet perturb mitochondrial energy metabolism and transcriptional control of lipid-handling in liver

Fig. 7

Predicted upstream regulators of gene expression in microarray. Legend: Upstream regulator analysis on gene expression in microarray was restricted to transcription factors with at least 5 target genes in the list of differentially expressed genes (absolute fold change ≥ 1.5 and nominal P-value ≤ 0.01) for a given diet or genotype comparison. a Nfe2l2-targeted genes in Acads−/− mutant mice fed high-fat (HF) vs. low-fat (LF) diet. b Ppara-targeted genes in HF-fed Acads−/− vs. Acads+/+ mice. Pi = neglogP*logratio. Genes whose direction of expression was consistent with activation of Nfe2l2 (a) or Ppara (b) are colored in black and those with inconsistent direction of expression are shown in white. J, BALB/cByJ or Acads−/−; KZ, BALB/cByKZ or Acads+/+

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