Table 1 Protective effect of unsaturated NEFAs against PA-induced toxicity and relative lipid droplet area linked with the correlation coefficient for each group
NEFA | Half-maximal protective concentration (μM) | Lipid droplet area after incubation with 100 μM NEFA (% of cell area) | Correlation coefficient for each group | P value for each group |
|---|---|---|---|---|
C18:1 | 32.8 ± 2.2 (6) | 7.3 ± 1.3 (5) | C18-FFA: +0.52 | C18-FFA: 0.37 |
C18:2 | 11.4 ± 1.2 (5) | 15.1 ± 2.8 (5) | ||
α-C18:3 | 24.0 ± 1.8 (4) | 2.4 ± 0.6 (5) | ||
γ-C18:3 | 27.2 ± 1.6 (4) | 2.6 ± 0.5 (5) | ||
C18:4 | > 100.0 (5) | 1.9 ± 0.3 (5) | ||
C20:1 | 17.2 ± 1.6 (6) | 26.5 ± 4.9 (5) | C20-FFA: −0.63 | C20-FFA: 0.25 |
C20:2 | 6.0 ± 0.6 (4) | 19.2 ± 2.9 (5) | ||
C20:3 | 10.4 ± 1.2 (4) | 8.1 ± 1.3 (5) | ||
C20:4 | 8.6 ± 0.6 (4) | 2.7 ± 0.6 (5) | ||
C20:5 | 5.4 ± 0.6 (4) | 3.9 ± 1.0 (5) | ||
C22:1 | 88.6 ± 22.8 (6) | 19.7 ± 4.1 (5) | C22-FFA: −0.89 | C22-FFA: 0.11 |
C22:2 | 42.0 ± 6.8 (4) | 18.9 ± 2.7 (5) | ||
C22:4 | 8.6 ± 1.4 (5) | 12.1 ± 2.5 (5) | ||
C22:6 | 10.8 ± 3.2 (5) | 11.8 ± 2.4 (5) | ||
Total value | 0.04 | 0.89 |