Fig. 1

Serum parameters during OGTT or IPITT and hepatic glucose and glycogen levels after these tests. a. Serum glucose levels before (0 min) and during (30, 60, 90 and 120 min) an intraperitoneal (IP) insulin tolerance test (IPITT). C + I, control rats that received an IP insulin bolus; PF + I, pair-fed rats that received an IP insulin bolus; L + I, rats treated with chronic icv leptin infusion that received an IP insulin bolus. b. Serum glucose levels before (0 min) and during (15, 30, 60 and 120 min) an oral glucose tolerance test (OGTT). C + G, control rats that received oral glucose; PF + G, pair-fed rats that received oral glucose; L + G, rats treated with chronic icv leptin infusion that received oral glucose. c. Serum insulin levels before and during an OGTT. d. Hepatic glucose levels after an IPITT. e. Hepatic glucose levels after an OGTT. f. Hepatic glycogen concentrations after an IPITT. g. Hepatic glycogen concentrations after an OGTT. *p < 0.05 vs. C, ^# p < 0.05 vs PF, &p < 0.05 vs. previous time-point in Fig. 1a-c or *p < 0.05, **p < 0.01 vs. C or PF in Fig. 1d-g