The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome

Table 3 Adjusted ORs (95 % CI) for metabolic syndrome according to quartiles of dietary pattern scores^a

	Q1	Q2	Q3	Q4	P for trend	P for interaction
Western dietary pattern						0.04
GG	1.	1.37 (0.77–2.45)	1.21 (1.09–2.11)	1.41 (0.77–2.17)	0.32
GA + AA	0.75 (0.41–1.35)	1.25 (0.75–2.08)	1.49 (0.87–2.53)	1.71 (1.04–2.41)	0.007
Healthy dietary pattern						0.82
GG	1	1.16 (0.68–1.37)	1.20 (0.67–2.13)	0.89 (0.51–1.53)	0.93
GA + AA	0.87 (0.49–1.54)	1.15 (0.68–1.94)	1.21 (0.74–2.08)	1.29 (0.77–2.17)	0.41
SFA						0.03
GG	1	1.77 (1.05–2.34)	1.10 (0.67–1.83)	0.83 (0.47–1.47)	0.50
GA + AA	0.90 (0.50–1.64)	1.24 (0.74–2.08)	1.43 (0.87–2.36)	1.76 (0.99–2.14)	0.01

OR odds ratio, Q quartiles of dietary pattern scores or SFA (Q1 < 7.75, Q2:7.75–9.52, Q3:9.52–11.51 and Q4 > 11.51 % of energy), SFA saturated fatty acid
^aORs (95 % CI) were calculated by using conditional logistic regression model, adjusted for baseline BMI and the interaction term (SNP × dietary pattern scores)
Participants were matched classified (8 groups) according to quartiles of dietary pattern scores and rs12970134 genotypes
The lowest quartile of dietary pattern scores and homozygote genotype of major allele were used as the reference group