Table 1 Stages of the kinases insensitivity under disease conditions
From: Chronic over-nutrition and dysregulation of GSK3 in diseases
Stage | Model system | PI3K activity | Akt activity | GSK3 activity | Insensitive kinase | Phenotype |
|---|---|---|---|---|---|---|
0 | Male Sprague Dawley (SD) Rats | High | High | Low | None | Early insulin resistance |
1 | Human retinal pigment epithelial cells (HRPE) treated with VEGF | High | High | High | GSK3 | Low growth |
2 | Human monocytes overexpressing IL17RC or treated with VEGF | High | Unchanged or low | High | GSK3, Akt | Low growth |
3 | HRPE overexpressing IL17RC | Low | Low | High | GSK3, Akt, PI3K | Low growth |