Table 1 Embryonic phenotypes of mice treated by lometrexol (DDATHF)
DDTHF (mg kg−1) | Litters (n) | Embryos (n) | Normal n (%) | Resorption n (%) | Growth retardation n (%) | NTDs n (%) | Other malformations n (%) |
|---|---|---|---|---|---|---|---|
0 | 8 | 62 | 60 (96.8) | 2 (3.2) | 0 (0) | 0 (0) | 0 (0) |
15 | 7 | 50 | 47 (94) | 2 (4) | 1 (2) | 0 (0) | 0 (0) |
30 | 5 | 38 | 29 (76.3) | 5 (13.2) | 2 (5.3) | 1 (2.6) | 1a (2.6) |
35 | 4 | 31 | 15 (48.4) | 8 (25.8) | 4 (12.9) | 2 (6.5) | 1a;1b (6.5) |
40 | 9 | 65 | 8 (12.3) | 21 (32.3) | 14 (21.5) | 20 (30.8) | 2a (3.1) |
45 | 5 | 34 | 2 (5.9) | 21 (61.8) | 9 (26.5) | 2 (5.9) | 0 (0) |
60 | 4 | 29 | 0 (0) | 29 (100) | 0 (0) | 0 (0) | 0 (0) |