Effects of dietary fat subtypes on glucose homeostasis during pregnancy in rats

Nutrition & Metabolism

Table 1 Body weight and biochemical analyses (N = 7–8 per group)

	CHOW		N-3		N-6		P-value
	Non-pregnant	Pregnant	Non-pregnant	Pregnant	Non-pregnant	Pregnant	Pregnancy	Diet	Interaction
Before dietary interventions
Weight [g]	241 ± 3	242 ± 2	245 ± 3	242 ± 1	246 ± 3	246 ± 4	NS	NS	NS
After dietary interventions
Weight [g]	265 ± 3	303 ± 5	284 ± 2	319 ± 4	287 ± 3	319 ± 2	<0.001	< 0.001	NS
Fasting glucose [mmol/L]	5.78 ± 0.25	4.41 ± 0.12	6.54 ± 0.52	3.91 ± 0.33	6.83 ± 0.53	6.01 ± 0.34	< 0.001	< 0.01	NS
Fasting insulin [pmol/L]	161 ± 26	280 ± 52	189 ± 36	116 ± 19	162 ± 28	305 ± 45	< 0.05	NS	< 0.01
IVGTT glucose AUC[min*mmol/L]^a	270 ± 20	183 ± 6	300 ± 23	219 ± 12	325 ± 18	260 ± 12	< 0.001	< 0.01	NS
IVGTT insulin AUC[min*nmol/L]^a	11.9 ± 1.4	27.2 ± 3.9	10.3 ± 0.7	9.4 ± 1.1	17.0 ± 2.7	18.9 ± 2.9	< 0.01	< 0.001	< 0.01
Liver triglycerides [mmol/mg]	8.30 ± 0.69	7.79 ± 0.56	6.45 ± 0.89	6.13 ± 0.70	10.7 ± 0.89	8.31 ± 1.00	NS	< 0.001	NS

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