Animal models of metabolic syndrome: a review

Nutrition & Metabolism

Table 1 Effects of fructose- and sucrose-enriched diets on the development of MetS

Researchers (Year)	Types of diet	Treatment length	Strains of animal	Components of metabolic syndrome
Researchers (Year)	Types of diet	Treatment length	Strains of animal	Obesity	Hyperglycemia	Hypertension	Dyslipidemia
Thirunavukkarasu et al. [41]	High-fructose diet	3 weeks	Male Wistar rats	-	✓	✓	-
Sanchez-Lozada et al. [42]	High-fructose diet (60 %)	8 weeks	Male Sprague-Dawley rats	-	-	✓	✓
Sanchez-Lozada et al. [42]	Fructose drinking water (10 %)	8 weeks	Male Sprague-Dawley rats	-	-	✓	✓
Shahraki et al. [105]	High-fructose diet	8 weeks	Male Wistar rats	✗	✓	-	✓
Mahmoud and Elshazly [106]	Fructose drinking water (10 %)	12 weeks	Male Wistar rats	✓	✓	✓	✓
Mansour et al. [107]	High-fructose diet	16 weeks	Male Wistar albino rats	✓	✓	-	✓
Mamikutty et al. [108]	Fructose drinking water	8 weeks	Male Wistar rats	✓	✓	✓	✓
Di Luccia et al. [109]	High-fructose diet	8 weeks	Male Sprague-Dawley rats	✓	✓	-	✓
Jurgens et al. [35]	Fructose drinking water (15 %)	10 weeks	Male NMRI mice	✓	-	-	-
	Sucrose soft drink (10 %)			✗	-	-	-
	Non-caloric soft drink			✗	-	-	-
Oron-Herman et al. [51]	High-sucrose diet	7 weeks	Male spontaneously hypertensive rats	✗	✓	✓	✗
Oron-Herman et al. [51]	High-fructose diet	7 weeks	Male Sprague-Dawley rats	✗	✓	✓	✓
Aguilera et al. [45]	Sucrose drinking water (30 %)	21 weeks	Male Wistar rats	✓	-	✓	✓
Vasanji et al. [49]	Sucrose drinking water (32 %)	10 weeks	Male Sprague-Dawley rats	-	✓	-	✓
Pang et al. [50]	High-sucrose diet	6 weeks	Male Sprague-Dawley rats	-	✗	✓	✓

Table represents the effects of fructose- and sucrose-enriched diets on each component of MetS. The symbol ‘✓’ and ‘✗’ indicate the presence and absence of significant effect of the sign of MetS respectively, while ‘-’ indicates the effects on the component not being evaluated in the study

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