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Table 5 Overall merits and caveats of various types of MetS animal model

From: Animal models of metabolic syndrome: a review

Diet-induced model of MetS
Examples: Induction by fructose drinking water, high fat diet, and high-carbohydrate high-fat diet
Pros Cons
➢ Suitable for the investigations of non-genetic lifestyle-dependent MetS in humans
➢ Inexpensive (dependent on the kind of diet)
➢ Delayed onset of MetS
➢ A lengthy duration of diet regimen (usually takes up to 16 weeks)
Genetic model of MetS
Examples: ZF rat, ZDF rat, DS/obese rat, Koletsky rat, POUND mouse
Pros Cons
➢ Severe and spontaneous occurring MetS ➢ Do not resemble the criteria of MetS in humans with intact leptin receptor gene
➢ Mutation in leptin or leptin receptor gene rarely occur in humans
➢ Costly
➢ Mutations/deficiencies in animals are not easily manipulated
Drug/chemical-induced model of MetS
Example: Induction by glucocorticoids and antipsychotic drugs
Pros Cons
➢ Suitable for the investigations of drug-related MetS in human
➢ Inexpensive
➢ Delayed onset of MetS