Fig. 2

Comparative metabolic profiling of U87 cells cultivated in the presence of glucose and pyruvate. Fold changes (log₂-transformed) of intracellular metabolite abundances are indicated with regard to the highest concentration of glucose employed (25 mM; set to log₂(1) = 0) for glucose concentrations of 11 mM (11 Glc), 5.5 mM (5.5 Glc) or for medium without glucose containing 5 mM pyruvate instead (Pyr). Identified metabolites were grouped in dependence on their metabolic role: TCA: metabolites associated with the tricarboxylic acid cycle; lipid synthesis: metabolites associated with lipid synthesis; glycolysis: glycolytic metabolites; nucleobase/nucleotides; monosaccharides; disaccharides; sugar phosphates; amino acids; amino acid metabolism: metabolites associated with amino acid metabolism; other: other metabolites not unequivocally associated with the other pathways indicated. The average of the fold changes from the metabolites in each group is indicated as “average”