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Fig. 3 | Nutrition & Metabolism

Fig. 3

From: Long-term consumption of an obesogenic high fat diet prior to ischemia-reperfusion mediates cardioprotection via Epac1-dependent signaling

Fig. 3

Myocardial tolerance to ischemia-reperfusion (I/R) injury after long-term feeding of an obesogenic high fat diet. Wild type (wt), Epac 1 (Epac1−/−) and Epac 2 (Epac2−/−) deficient mice were exposed to long-term feeding of either a normal chow diet (ND) or a high fat diet (HFD). At the end of the feeding protocol, the excised mice hearts were subjected to global ischemia (GI, 30min) and reperfusion (Rep, 60min) in a Langendorff perfusion model. Infarct size is expressed as percentage of the region at risk of infarction. Values are mean ± SEM and n ≥ 6. The numbers given in the figure indicate significance levels

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