From: Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
Studies | Experimental model | Dietary intervention | Main outcomes measured |
---|---|---|---|
Cani 2005a [129] | 〉 Male Wistar rats | Oligofructose (10% of dietb) | ↑ GLP-1 concentrations in the proximal and medial colon ↑ Proglucagon mRNA concentrations in the caecum and proximal colon ↓ Triglyceride blood and hepatic concentrations ↓ Food and energy intake ↓ Body weight gain |
Cani 2005b [132] | 〉 Streptozotocin-treated diabetic rats | Oligofructose (10% of dietb) | ↑ Proglucagon mRNA concentrations in the proximal colon ↑ Pro-hormone convertase 1 mRNA concentrations in the proximal colon ↑ GLP-1 concentrations in the portal vein ↑ Glucose tolerance ↑ Insulin and C-peptide blood concentrations ↑ Pancreatic β-cell mass ↓ Food and energy intake |
Cani 2005c [131] | 〉 Healthy men and women | Oligofructose (16 g/day) | ↓ Energy intake over 24 hours ↑ Satiety ↓ Hunger ↓ Prospective food consumption |
Cani 2006 [133] | 〉 Male C57BL/6 J mice with high-fat feeding-induced diabetes | Oligofructose (10% of dietb) | ↑ GLP-1 concentrations in the proximal colon ↑ GLP-1 concentrations in the portal vein ↑ Proglucagon mRNA concentrations in the proximal colon ↑ Blood and pancreatic insulin concentrations ↓ Fasting and postprandial blood glucose concentrations |
Cani 2007 [134] | 〉 Male Wistar rats | Oligofructose (10% of dietb) | ↑ GLP-1 concentrations in the portal vein and proximal colon ↑ Proglucagon mRNA concentrations in the proximal colon ↑ L-cell number in the proximal colon ↑ Neurogenin-3 and Neuro-D mRNA concentrations in the proximal colon ↓ Food and energy intake ↓ Body weight gain |
Zhou 2008 [130] | 〉 Sprague-Dawley rats 〉 Streptozotocin-treated C57BL/6 J mice | Resistant starch (53% of dietb) | ↑ GLP-1 blood concentrations ↑ PYY blood concentrations ↓ Variation in blood glucose and insulin concentrations ↑ Proglucagon and PYY colonic mRNA concentrations ↑ Glucose tolerance in diabetic mice |