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Table 1 Chronica effects of non-digestible carbohydrates on glucagon-like peptide-1 (GLP-1) secretion and associated outcomes

From: Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review

Studies Experimental model Dietary intervention Main outcomes measured
Cani 2005a
[129]
〉 Male Wistar rats Oligofructose
(10% of dietb)
↑ GLP-1 concentrations in the proximal and medial colon
↑ Proglucagon mRNA concentrations in the caecum and proximal colon
↓ Triglyceride blood and hepatic concentrations
↓ Food and energy intake
↓ Body weight gain
Cani 2005b
[132]
〉 Streptozotocin-treated diabetic rats Oligofructose
(10% of dietb)
↑ Proglucagon mRNA concentrations in the proximal colon
↑ Pro-hormone convertase 1 mRNA concentrations in the proximal colon
↑ GLP-1 concentrations in the portal vein
↑ Glucose tolerance
↑ Insulin and C-peptide blood concentrations
↑ Pancreatic β-cell mass
↓ Food and energy intake
Cani 2005c
[131]
〉 Healthy men and women Oligofructose (16 g/day) ↓ Energy intake over 24 hours
↑ Satiety
↓ Hunger
↓ Prospective food consumption
Cani 2006
[133]
〉 Male C57BL/6 J mice with high-fat feeding-induced diabetes Oligofructose
(10% of dietb)
↑ GLP-1 concentrations in the proximal colon
↑ GLP-1 concentrations in the portal vein
↑ Proglucagon mRNA concentrations in the proximal colon
↑ Blood and pancreatic insulin concentrations
↓ Fasting and postprandial blood glucose concentrations
Cani 2007
[134]
〉 Male Wistar rats Oligofructose
(10% of dietb)
↑ GLP-1 concentrations in the portal vein and proximal colon
↑ Proglucagon mRNA concentrations in the proximal colon
↑ L-cell number in the proximal colon
↑ Neurogenin-3 and Neuro-D mRNA concentrations in the proximal colon
↓ Food and energy intake
↓ Body weight gain
Zhou 2008
[130]
〉 Sprague-Dawley rats
〉 Streptozotocin-treated C57BL/6 J mice
Resistant starch
(53% of dietb)
↑ GLP-1 blood concentrations
↑ PYY blood concentrations
↓ Variation in blood glucose and insulin concentrations
↑ Proglucagon and PYY colonic mRNA concentrations
↑ Glucose tolerance in diabetic mice
  1. GLP-1 Glucagon-like peptide-1, mRNA Messenger ribonucleic acid, PYY Peptide tyrosine-tyrosine
  2. a 10 days - 1 year interventions
  3. b weight : weight proportion