From: Nutritional modulation of endogenous glucagon-like peptide-1 secretion: a review
Studies | Experimental model | Dietary intervention | Main outcomes measured |
---|---|---|---|
Thomsen 1999 [137] | 〉 Healthy men and women | MUFAs from olive oila (80 g) | ↑ GLP-1 blood concentrations ↑ Glucose-insulinotropic peptide blood concentrations |
Thomsen 2003 [138] | 〉 Men and women with T2D | MUFAs from olive oila (80 g) | ↑ GLP-1 blood concentrations ↓ Triglyceride blood concentrations ↑ High-density lipoprotein cholesterol blood concentrations |
Hirasawa 2005 [136] | 〉 Male C57/B6 rats | α-linolenic acid (0.1 μmol)a | ↑ GLP-1 blood concentrations ↑ Insulin blood concentrations |
Prieto 2005 [139] | 〉 Wistar rats | MUFAs from olive oilb,c | ↑ GLP-1 blood concentrations ↑ Glucose-stimulated insulin secretion ↑ Glucose tolerance |
Cancelas 2006 [140] | 〉 Streptozotocin-treated diabetic rats | MUFAs from olive oilb,c | ↑ GLP-1 postprandial secretion ↑ Insulin sensitivity ↓ Weight gain |
Adachi 2006 [142] | 〉 Male C57BL/6 J mice 〉 Diabetic male NSY mice 〉 C3H/He mice | α-linolenic acid (0.3 μmol)a | ↑ GLP-1 blood concentrations ↑ Insulin blood concentrations ↓ Blood glucose concentrations |
Paniagua 2007 [141] | 〉 Insulin resistant men and women | MUFAs from an olive-oil containing Mediterranean diet (23% of total energy intake)b | ↑ Postprandial GLP-1 concentrations ↑ Insulin sensitivity ↓ Postprandial insulin secretion ↓ Fasting and postprandial blood glucose concentrations |
Tanaka 2008 [143] | 〉 Male Wistar rats | α-linolenic acid (3 μmol)a,b | ↑ GLP-1 blood concentrations ↑ pancreatic β-cell number and mass |
Cheshmehkani 2015 [144] | 〉 Male Sprague-Dawley rats | Fish or flaxseed oilb,d (10% of diet) | ↑ FFAR4 expression in the colon ↓ TNFα blood concentrations |