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Fig. 3 | Nutrition & Metabolism

Fig. 3

From: Long-term intake of saccharin decreases post-absortive energy expenditure at rest and is associated to greater weight gain relative to sucrose in wistar rats

Fig. 3

a. VO2 consumption at baseline, 5th and 12th weeks. Group labels: SAC (Saccharin, n = 12) and SUC (Sucrose, n = 10). Analyzed by ANOVA of repeated measures [F(1, 20.01) = .13, p = .72]; bar chart indicate analysis of AUC(0-12wk) by Student t-test [t(20) = .43, p = .67]. Error bars indicate SE. There was no statistical difference. b. VCO2 production at baseline, 5th and 12th weeks. Group labels: SAC (Saccharin, n = 12) and SUC (Sucrose, n = 10). Analyzed by ANOVA of repeated measures [F(1.42, 28.39) = 14.92, p < .001]; bar chart indicate analysis of AUC(0-12wk) by Student t-test [t(20) = 6.86, p = < .001]. Error bars indicate SE. Asterisks indicate p ˂ .001. c. Respiratory Exchange Ratio (RER) at baseline, 5th and 12th weeks. Group labels: SAC (Saccharin, n = 12) and SUC (Sucrose, n = 10). Analyzed by ANOVA of repeated measures [F(1.18, 23.59) = 6.26, p = .016]; bar chart indicate analysis of AUC(0-12wk) by Student t-test [t(20) = 2.82, p = .011]. Error bars indicate SE. Asterisks indicate: *: p ˂ .05; ***: p ˂ .001. d. Energy expenditure (EE) estimated by Weir's equation at baseline, 5th and 12th weeks. Group labels: SAC (Saccharin, n = 12) and SUC (Sucrose, n = 10). Analyzed by ANOVA of repeated measures. There was statistical difference between groups on 12th week (p = .009). Error bars indicate SE. Asterisk indicate p ˂ .05

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