Fig. 1

Metabolism of PA. PA can be synthesized from various sources. A de novo pathway originates from G3P. G3P is acetylated twice, requiring fatty-acyl-CoA for its acetylation. First it is acetylated by GPAT and then by LPAAT. A second pathway uses PC. PC is hydrolyzed by PLD to produce PA. Finally, PA can be produced by the phosphorylation of DAG by DAG kinase (DGK). DAG is derived from triacylglycerols and phosphatidylinositol. PA phosphatase (PA P’tase) is responsible for dephosphorylation of PA to DAG. Various CDP-diacylglycerol synthases produce CDP-diacylglycerol from PA. Figure based on [27]