Table 2 Anticancer activity of GS in in vivo animal experimental models
From: Potential therapeutic targets of Guggulsterone in cancer
Cancer Type | Model/System | Antitumor effects | References |
|---|---|---|---|
Pancreatic cancer | Pancreatic cancer cell line xenograft tumors | ↓ tumor size | [39] |
Colon Cancer | HT-29 xenograft tumors | ↓ tumor size | [50] |
Esophageal cancer | Esophageal adenocarcinoma cell lines | ↓ tumor size | [47] |
Breast cancer | MCF7 xenograft tumors | ↓Bcl-2 and P-glycoprotein expression ↑Chemosensivity of doxorubicin in vivo | [75] |
Prostate cancer | DU145 prostate cancer cells implanted in mouse | ↓ tumor size, ↓ angiogenesis↓ VEGFR-2 | [28] |