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Table 2 Anticancer activity of GS in in vivo animal experimental models

From: Potential therapeutic targets of Guggulsterone in cancer

Cancer Type Model/System Antitumor effects References
Pancreatic cancer Pancreatic cancer cell line xenograft tumors ↓ tumor size [39]
Colon Cancer HT-29 xenograft tumors ↓ tumor size [50]
Esophageal cancer Esophageal adenocarcinoma cell lines ↓ tumor size [47]
Breast cancer MCF7 xenograft tumors ↓Bcl-2 and P-glycoprotein expression
↑Chemosensivity of doxorubicin in vivo
[75]
Prostate cancer DU145 prostate cancer cells implanted in mouse ↓ tumor size, ↓ angiogenesis↓ VEGFR-2 [28]