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Table 4 Associations of IR (HOMA-IR > 1.6 or 2) with ALT/AST and other metabolic factors in logistic regression analyses

From: Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population

 

HOMA-IR>1.6

HOMA-IR>2

 

Non-central obesity

Central obesity

Non-central obesity

Central obesity

ALT/AST

1.90(1.74–2.06)***

2.06(1.85–2.28)***

1.89(1.70–2.11)***

2.02(1.81–2.25)***

ALT

1.55(1.44–1.68)***

1.58(1.44–1.72)***

1.46(1.33–1.61)***

1.64(1.49–1.80)***

AST

1.08(1.00–1.17)

1.07(0.99–1.16)

0.98(0.88–1.09)

1.17(1.08–1.28) ***

TG

1.72(1.59–1.85)***

1.60(1.46–1.75)***

1.67(1.52–1.83)***

1.63(1.48–1.79)***

HDL

0.64(0.60–0.70)***

0.71(0.65–0.78)***

0.63(0.57–0.70) ***

0.69(0.62–0.76)***

BMI

2.02(1.83–2.23)***

1.87(1.67–2.09)***

1.93(1.70–2.18) ***

1.89(1.67–2.13)***

SBP

1.26(1.16–1.38)***

1.19(1.09–1.31)***

1.28(1.14–1.44) ***

1.24(1.12–1.37)***

DBP

1.18(1.09–1.28)***

1.16(1.07–1.27) **

1.13(1.01–1.25) *

1.20(1.09–1.32) ***

  1. Data were odds ratio (95% confidence interval). HOMA-IR homeostasis model assessment-insulin resistance, ALT alanine aminotransferase, AST aspartate aminotransferase, TG triglycerides, HDL high-density lipoprotein, BMI body mass index, WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure
  2. Adjusted odds ratios for each 1-SD increment of each potential risk factor associated with insulin resistance were calculated. The model has been adjusted for age, gender, smoking, drinking, residence area, economic status and HbA1c. *P<0.05; **P<0.01; ***P<0.001