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Table 5 AUC(95%CI) of markers for insulin resistance (HOMA-IR>1.6) in subjects categorized by WC

From: Serum alanine aminotransferase/aspartate aminotransferase ratio is one of the best markers of insulin resistance in the Chinese population

 

Non-central obesity

Central obesity

 

AUC(95%CI)

P1

P2

AUC(95%CI)

P1

P2

ALT/AST

0.66(0.64–0.68)

<0.001

 

0.68(0.66–0.70)

<0.001

 

ALT

0.60(0.58–0.62)

<0.001

<0.001

0.64(0.62–0.66)

<0.001

<0.001

AST

0.48(0.46–0.50)

0.016

<0.001

0.52(0.49–0.54)

0.191

<0.001

TG

0.64(0.63–0.66)

<0.001

0.21

0.64(0.62–0.66)

<0.001

0.002

HDL

0.39(0.37–0.41)

<0.001

0.002

0.41(0.39–0.43)

<0.001

<0.001

BMI

0.64(0.63–0.66)

<0.001

0.22

0.65(0.63–0.67)

<0.001

0.006

WC

0.60(0.58–0.62)

<0.001

<0.001

0.60(0.58–0.62)

<0.001

<0.001

SBP

0.53(0.51–0.55)

0.001

<0.001

0.53(0.51–0.55)

0.007

<0.001

DBP

0.53(0.51–0.55)

0.001

<0.001

0.55(0.52–0.57)

<0.001

<0.001

Model 1

0.69(0.67–0.71)

<0.001

 

0.69(0.67–0.71)

<0.001

 

Model 2

0.72(0.70–0.74)*

<0.001

 

0.73(0.72–0.75)*

<0.001

 
  1. Data were expressed as area under curve (95% confidence interval). Model 1 included age, gender, BMI, SBP, TG, LDL and HDL. Model 2 further included ALT/AST. ROC receiver operating characteristics, AUC area under ROC curve, HOMA-IR homeostasis model assessment-insulin resistance, ALT alanine aminotransferase, AST aspartate aminotransferase, TG triglycerides, HDL high-density lipoprotein, BMI body mass index, WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure. P1: The diagnostic value for ROC, two tail significance. P2: Difference of AUC compared to the ALT/AST ratio model, two tail significance (Z test). *: P<0.001, difference of AUCs between Model 1 and Model 2, two-tailed significance (Z test)
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Nutrition & Metabolism

ISSN: 1743-7075

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