Skip to main content

Table 2 Significantly modulated canonical pathways, molecular and cellular functions, and transcription regulators for low fat (LF)-specific, high fat (HF)-specific, meal-responsive, HF-delay, and LF-HF-different genes

From: Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine

  LF-specific genes HF-specific genes Meal-responsive genes HF-delay genes LF-HF different genes
Top 3 canonical pathways
1 ERK5 signaling Calcium signaling Aldosterone signaling in epithelial cells   Glycerolipid metabolism
2   LXR/RXR activation Protein ubiquitination pathway   Actin cytoskeleton signaling
3   LPS/IL-1 mediated inhibition of RXR function    
Top 3 molecular and cellular functions
1 Carbohydrate metabolism Lipid metabolism Cellular function and maintenance Lipid metabolism Lipid metabolism
2 Cellular function and maintenance Small molecule biochemistry Post-translational modification Molecular transport Small molecule biochemistry
3 Cellular growth and proliferation Molecular transport Protein folding Small molecule biochemistry Molecular transport
Top 3 transcription regulators
1 CREB1 PPARA FOXO1 RBPJL NR5A2
2 CEBPB SMAD3 AIP PTF1A RBPJL
3 FOXO1 PPARGC1A HIF1A MLX Pdx1
  1. Abbreviations: AIP aryl-hydrocarbon receptor-interacting protein, CEBPB CCAAT/enhancer-binding protein beta, CREB1 cAMP responsive element binding protein 1, ERK5 extracellular signal regulated kinase 5, EPAS1 endothelial PAS domain-containing protein 1, FOXO1 forkhead box protein O1, HIF1A hypoxia-inducible factor 1 alpha subunit, IL-1 interleukin 1, LPS lipopolysaccharides, LXR liver X receptor, MLX Max-like protein X, NR4A1 nuclear receptor subfamily 4 group A member 1, NR5A2 nuclear receptor subfamily 5 group A member 2, Pdx1 pancreatic and duodenal homeobox 1, PPARA peroxisome proliferator-activated receptor alpha, PPARGC1A PPAR gamma coactivator 1-alpha, PTF1A pancreas transcription factor 1 subunit alpha, RBPJL recombination signal binding protein for immunoglobulin kappa J region-like, RXR retinoid X receptor