Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine

Table 2 Significantly modulated canonical pathways, molecular and cellular functions, and transcription regulators for low fat (LF)-specific, high fat (HF)-specific, meal-responsive, HF-delay, and LF-HF-different genes

	LF-specific genes	HF-specific genes	Meal-responsive genes	HF-delay genes	LF-HF different genes
Top 3 canonical pathways
1	ERK5 signaling	Calcium signaling	Aldosterone signaling in epithelial cells		Glycerolipid metabolism
2		LXR/RXR activation	Protein ubiquitination pathway		Actin cytoskeleton signaling
3		LPS/IL-1 mediated inhibition of RXR function
Top 3 molecular and cellular functions
1	Carbohydrate metabolism	Lipid metabolism	Cellular function and maintenance	Lipid metabolism	Lipid metabolism
2	Cellular function and maintenance	Small molecule biochemistry	Post-translational modification	Molecular transport	Small molecule biochemistry
3	Cellular growth and proliferation	Molecular transport	Protein folding	Small molecule biochemistry	Molecular transport
Top 3 transcription regulators
1	CREB1	PPARA	FOXO1	RBPJL	NR5A2
2	CEBPB	SMAD3	AIP	PTF1A	RBPJL
3	FOXO1	PPARGC1A	HIF1A	MLX	Pdx1

Abbreviations: AIP aryl-hydrocarbon receptor-interacting protein, CEBPB CCAAT/enhancer-binding protein beta, CREB1 cAMP responsive element binding protein 1, ERK5 extracellular signal regulated kinase 5, EPAS1 endothelial PAS domain-containing protein 1, FOXO1 forkhead box protein O1, HIF1A hypoxia-inducible factor 1 alpha subunit, IL-1 interleukin 1, LPS lipopolysaccharides, LXR liver X receptor, MLX Max-like protein X, NR4A1 nuclear receptor subfamily 4 group A member 1, NR5A2 nuclear receptor subfamily 5 group A member 2, Pdx1 pancreatic and duodenal homeobox 1, PPARA peroxisome proliferator-activated receptor alpha, PPARGC1A PPAR gamma coactivator 1-alpha, PTF1A pancreas transcription factor 1 subunit alpha, RBPJL recombination signal binding protein for immunoglobulin kappa J region-like, RXR retinoid X receptor

ISSN: 1743-7075