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Table 3 Effects of scFOS/OF supplementation on glucose homeostasis in animals other than rodents

From: Fructo-oligosaccharides and glucose homeostasis: a systematic review and meta-analysis in animal models

Animal model Diet FOS dose Duration Fasting condition Postprandial condition Other metabolic results Microbiota analysis (yes/no) Included in meta-analysis (yes/no) References
G I Method G I
Healthy male veal calves Whole milk + milk replacer 10 g scFOS/d 3 w = = Lactose feeding ↓ (after 2 h to 5 h) ↑ (after 2 h) ↓ lactate after lactose feeding (after 3 h and 4 h) = TG (blood) NO NO [29]
Obese male Arabian horses Concentrate feeds and hay 45 g scFOS/d 6 w = FSIGTT = Sg ↓ AIRi ↑ SI = TG and leptin (fasting blood) NO NO [28]
Obese male Beagle dogs 32% E fat, 44% E CHO 1% scFOS 6 w = = Euglycemic hyperinsulinaemic clamp ↑ glucose infusion ↑ insulin sensitivity ↓ HOMA-IR = TG and Chol (blood) NO NO [30]
Obese male Beagle dogs on weight-loss program 9.5% E fat, 56.5% E CHO 3% scFOS Vs 1% scFOS 6 w =a =a ND ND ND ↓ haptoglobin NO NO [31]
Normal or obese short-hair neutered cats 38% E fat, 8% E CHO 2.5% mix OF/inulin 4 w = = IVGTT = = = Chol, NEFA, leptin NO NO [32]
  1. CHO carbohydrates, Chol cholesterol, d days, E energy, FOS fructo-oligosaccharides, G glucose, I insulin, ND no data, OF oligofructose, scFOS short-chain fructooligosaccharides, TG triglycerides, w weeks
  2. aFed condition not clearly indicated in the study