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Table 6 Effects of scFOS/OF supplementation on microbiota composition and/or fermentative activity

From: Fructo-oligosaccharides and glucose homeostasis: a systematic review and meta-analysis in animal models

Animal model

Diet

FOS dose

Duration

Microbiota fermentative activity

Microbiota composition

References

Male Wistar rats

11.8% E fat, 69.4% E CHO (starch or fructose)

10% OF

4 w

↑ caecum weight

↑ caecal SCFA (pool) content: ↓ acetate, ↑ propionate and butyrate

ND

[61]

C57BL/6J female mice, depleted or not in n-3 PUFA

14.3% E fat, 58.9% E CHO

0.2g OF/ d

24 d

↑ caecal tissue and content weight

Caecum (STD diet):

Bifidobacterium spp., Bacteroides-Prevotella

Lactobacillus spp.

Caecum (n-3 depleted diet):

Bifidobacterium spp., Lactobacillus spp.

= Bacteroides-Prevotella

[22]

Male C57BL/6J gnotobiotic mice

34.9% E fat, 26.3% E CHO

10% scFOS

6 w

↑ empty and full caecum weight

Faeces:

↑ Bifidobacteria, C. coccoides

C. leptum, ratio Bacteroides-Prevotella: C. coccoides

[46]

Male Sprague-Dawley rats, DIO

9.8% E fat, 77.5% E CHO

3% OF

6 w

ND

Caecum:

↑ Total bacteria

Lactobacillus, Bifidobacterium and Bacteroides/Prevotella,

C. leptum, C. cluster XI,

↓ % Firmicutes, ratio Firmicutes: Bacteroidetes

[17]

Male Sprague-Dawley rats, DIO

9.8% E fat, 77.5% E CHO

10% OF

8 w

↑ caecum weight

Caecum:

Bacteroides spp., Lactobacillus spp., Bifidobacterium spp., B. animalis

C. coccoides, C. leptum, Clostridium Cluster XI and I, Enterobacteriaceae

↓ Ratio Firmicutes: Bacteroidetes

[14]

Male Wistar rats – PX - 407

9.8% E fat, 77.5% E CHO

10% or 15% scFOS

6 w

ND

Caecum:

↑ Bifidobacteria and Lactobacilli

[56]

Male Sprague Dawley rats, DIO

g/100g: casein (20.0), sucrose (49.9), soybean oil (10.0), lard (10.0)

10% OF

7 w

↑ empty caecum weight

Faeces:

↑ Total bacteria

Bifidobacterium spp.

C. leptum

= Lactobacillus spp., C. coccoides, Bacteroides/Prevotella

[24]

Male Wistar rats, Streptozotocin

20.4% E fat, 59.9% E CHO

10% scFOS

2 – 6 w

↑ caecum weight

Caecum:

↑ Bifidobacteria, Lactobacilli

[19]

Ob/ob C57BL/6 mice

60% E fat, 20% E CHO

10% OF

5 w

↑ caecum and colon weight

Caecum (qPCR):

= Total bacteria

↑ Bifidobacterium spp., E. rectale/

C. coccoides group

↓ Firmicutes and Roseburia spp.

= Bacteroidetes, Lactobacillus spp., Bacteroides-Prevotella group

[18]

  1. CHO carbohydrates, d days, DIO diet-induced obesity, E energy, FOS fructo-oligosaccharides, G glucose, I insulin, ND no data, OF oligofructose, scFOS short-chain fructooligosaccharides, w weeks