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Table 6 Effects of scFOS/OF supplementation on microbiota composition and/or fermentative activity

From: Fructo-oligosaccharides and glucose homeostasis: a systematic review and meta-analysis in animal models

Animal model Diet FOS dose Duration Microbiota fermentative activity Microbiota composition References
Male Wistar rats 11.8% E fat, 69.4% E CHO (starch or fructose) 10% OF 4 w ↑ caecum weight
↑ caecal SCFA (pool) content: ↓ acetate, ↑ propionate and butyrate
ND [61]
C57BL/6J female mice, depleted or not in n-3 PUFA 14.3% E fat, 58.9% E CHO 0.2g OF/ d 24 d ↑ caecal tissue and content weight Caecum (STD diet):
Bifidobacterium spp., Bacteroides-Prevotella
Lactobacillus spp.
Caecum (n-3 depleted diet):
Bifidobacterium spp., Lactobacillus spp.
= Bacteroides-Prevotella
[22]
Male C57BL/6J gnotobiotic mice 34.9% E fat, 26.3% E CHO 10% scFOS 6 w ↑ empty and full caecum weight Faeces:
↑ Bifidobacteria, C. coccoides
C. leptum, ratio Bacteroides-Prevotella: C. coccoides
[46]
Male Sprague-Dawley rats, DIO 9.8% E fat, 77.5% E CHO 3% OF 6 w ND Caecum:
↑ Total bacteria
Lactobacillus, Bifidobacterium and Bacteroides/Prevotella,
C. leptum, C. cluster XI,
↓ % Firmicutes, ratio Firmicutes: Bacteroidetes
[17]
Male Sprague-Dawley rats, DIO 9.8% E fat, 77.5% E CHO 10% OF 8 w ↑ caecum weight Caecum:
Bacteroides spp., Lactobacillus spp., Bifidobacterium spp., B. animalis
C. coccoides, C. leptum, Clostridium Cluster XI and I, Enterobacteriaceae
↓ Ratio Firmicutes: Bacteroidetes
[14]
Male Wistar rats – PX - 407 9.8% E fat, 77.5% E CHO 10% or 15% scFOS 6 w ND Caecum:
↑ Bifidobacteria and Lactobacilli
[56]
Male Sprague Dawley rats, DIO g/100g: casein (20.0), sucrose (49.9), soybean oil (10.0), lard (10.0) 10% OF 7 w ↑ empty caecum weight Faeces:
↑ Total bacteria
Bifidobacterium spp.
C. leptum
= Lactobacillus spp., C. coccoides, Bacteroides/Prevotella
[24]
Male Wistar rats, Streptozotocin 20.4% E fat, 59.9% E CHO 10% scFOS 2 – 6 w ↑ caecum weight Caecum:
↑ Bifidobacteria, Lactobacilli
[19]
Ob/ob C57BL/6 mice 60% E fat, 20% E CHO 10% OF 5 w ↑ caecum and colon weight Caecum (qPCR):
= Total bacteria
↑ Bifidobacterium spp., E. rectale/
C. coccoides group
↓ Firmicutes and Roseburia spp.
= Bacteroidetes, Lactobacillus spp., Bacteroides-Prevotella group
[18]
  1. CHO carbohydrates, d days, DIO diet-induced obesity, E energy, FOS fructo-oligosaccharides, G glucose, I insulin, ND no data, OF oligofructose, scFOS short-chain fructooligosaccharides, w weeks