Skip to main content

Advertisement

Table 6 Effects of scFOS/OF supplementation on microbiota composition and/or fermentative activity

From: Fructo-oligosaccharides and glucose homeostasis: a systematic review and meta-analysis in animal models

Animal model Diet FOS dose Duration Microbiota fermentative activity Microbiota composition References
Male Wistar rats 11.8% E fat, 69.4% E CHO (starch or fructose) 10% OF 4 w ↑ caecum weight ↑ caecal SCFA (pool) content: ↓ acetate, ↑ propionate and butyrate ND [61]
C57BL/6J female mice, depleted or not in n-3 PUFA 14.3% E fat, 58.9% E CHO 0.2g OF/ d 24 d ↑ caecal tissue and content weight Caecum (STD diet): ↑Bifidobacterium spp., Bacteroides-PrevotellaLactobacillus spp. Caecum (n-3 depleted diet): ↑Bifidobacterium spp., Lactobacillus spp. = Bacteroides-Prevotella [22]
Male C57BL/6J gnotobiotic mice 34.9% E fat, 26.3% E CHO 10% scFOS 6 w ↑ empty and full caecum weight Faeces: ↑ Bifidobacteria, C. coccoidesC. leptum, ratio Bacteroides-Prevotella: C. coccoides [46]
Male Sprague-Dawley rats, DIO 9.8% E fat, 77.5% E CHO 3% OF 6 w ND Caecum: ↑ Total bacteria ↑ Lactobacillus, Bifidobacterium and Bacteroides/Prevotella, ↓ C. leptum, C. cluster XI, ↓ % Firmicutes, ratio Firmicutes: Bacteroidetes [17]
Male Sprague-Dawley rats, DIO 9.8% E fat, 77.5% E CHO 10% OF 8 w ↑ caecum weight Caecum: ↑ Bacteroides spp., Lactobacillus spp., Bifidobacterium spp., B. animalisC. coccoides, C. leptum, Clostridium Cluster XI and I, Enterobacteriaceae ↓ Ratio Firmicutes: Bacteroidetes [14]
Male Wistar rats – PX - 407 9.8% E fat, 77.5% E CHO 10% or 15% scFOS 6 w ND Caecum: ↑ Bifidobacteria and Lactobacilli [56]
Male Sprague Dawley rats, DIO g/100g: casein (20.0), sucrose (49.9), soybean oil (10.0), lard (10.0) 10% OF 7 w ↑ empty caecum weight Faeces: ↑ Total bacteria ↑ Bifidobacterium spp. ↓ C. leptum = Lactobacillus spp., C. coccoides, Bacteroides/Prevotella [24]
Male Wistar rats, Streptozotocin 20.4% E fat, 59.9% E CHO 10% scFOS 2 – 6 w ↑ caecum weight Caecum: ↑ Bifidobacteria, Lactobacilli [19]
Ob/ob C57BL/6 mice 60% E fat, 20% E CHO 10% OF 5 w ↑ caecum and colon weight Caecum (qPCR): = Total bacteria ↑ Bifidobacterium spp., E. rectale/ C. coccoides group ↓ Firmicutes and Roseburia spp. = Bacteroidetes, Lactobacillus spp., Bacteroides-Prevotella group [18]
  1. CHO carbohydrates, d days, DIO diet-induced obesity, E energy, FOS fructo-oligosaccharides, G glucose, I insulin, ND no data, OF oligofructose, scFOS short-chain fructooligosaccharides, w weeks