Trial | Results | Reference |
---|---|---|
Association of Serum 25-Hydroxyvitamin D concentrations with certain circulating blood parameters in Cirrhotic Patients. | Though supplementation of vitamin D considerably enhances serum levels of 25(OH) D, no significant effect either on liver function tests and fibrosis or on PTH and mineral metabolites was observed. | [201] |
Gene polymorphisms of the vitamin d receptor may prove a risk factor for development of HCC. | In chronic hepatitis C patients, the role of VDR ApoI polymorphism is crucial in the development of HCC | [202] |
25-hydroxyvitamin D deficiency as a prognostic marker in patients with HCC. | 25(OH) D3 is a marker metabolite for poor consequences and its deficiency is associated with advanced progression of HCC. | [203] |
Association between circulating vitamin D levels and the risk of developing HCC amongst Europeans. | There is an inverse association between the 25(OH) D serum concentrations and the risk of HCC. | [204] |
Mechanistic role of 1, 25(OH) 2D3 in the progression of hepatocellular carcinoma. | Decreased expression of HDAC2 and increased expression of p21 (WAF1/Cip1), repressed the progression of HCC on administration of 1, 25(OH) 2D3 suggesting a therapeutic role of the vitamin in potential drug developments. | [205] |
Tapping the 25(OH) D-induced cell growth inhibition potential for future targeted therapy in HCC patients. | 25(OH)D and CYP27B1 gene transfection therapy could well be targeted for future HCC management studies | [206] |
Effect of SNPs in VDR and DBP genes on HBV linked HCC risk amongst Chinese. | Polymorphisms of VDR rs2228570 and DBP rs7041 may be responsible for an increased susceptibility to HBV-related HCC amongst Chinese residents. | [22] |
Association of vitamin D and cytokine production in HCC | Up-regulation of p27(kip1) expression in immune cells and reduction in the production of cytokines may contribute towards the inhibition of HCC progression on administration of vitamin D | [207] |
Use of vitamin D, IL-6, and IL-17 concentrations as potential biomarkers in HCC patients for a more favorable prognosis | Vitamin D and the cytokines IL-6and IL-7 could be additionally used as prognostic markers in HCV and cirrhotic patients to suppress the development of HCC in them. | [208] |
Effect of vitamin D supplementation on levels of CYP24A1 mRNA in hepatocellular carcinoma cell lines. | In-vitro supplementation of 1, 25(OH) (2) D (3) results in marked increases of CYP24A1 mRNA expression in few, though not all, human HCC lines. | [209] |