Skip to main content

Table 5 Stratified analysis of the PPP1R3B genotypes and the risk of CAD or IS

From: Association between the PPP1R3B polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke in a southern Chinese Han population

Factor

Genotype

OR(95%CI)CAD

P CAD

OR(95%CI)IS

P IS

rs12785

Gender

 Male

TT

1

1

 

TA + AA

1.06(0.68–1.44)

0.830

1.15(0.80–1.56)

0.470

 Female

TT

1

1

 

TA + AA

1.76(1.13–2.73)

0.007

1.00(0.63–1.56)

0.970

Age, year

 ≤ 60

TT

1

1

 

TA + AA

1.34(0.73–1.89)

0.280

1.03(0.70–1.50)

0.980

 >  60

TT

1

1

 

TA + AA

1.24(0.85–1.82)

0.260

1.23(0.84–1.80)

0.280

BMI, kg/m2

 ≤ 24

TT

1

1

 

TA + AA

1.27(0.93–1.74)

0.970

1.25(0.91–1.71)

0.170

 >  24

TT

1

1

 

TA + AA

1.23(0.79–1.91)

0.370

0.80(0.49–1.32)

0.400

Smoking

 No

TT

1

1

 

TA + AA

1.34(0.97–1.87)

0.090

0.85(0.60–1.19)

0.330

 Yes

TT

1

1

 

TA + AA

1.15(0.78–1.71)

0.520

1.56(1.05–2.39)

0.009

Drinking

 No

TT

1

1

 

TA + AA

1.19(0.88–1.63)

0.270

1.06(0.77–1.45)

0.720

 Yes

TT

1

1

 

TA + AA

1.46(0.93–2.27)

0.100

1.03(0.66–1.61)

0.910

Hyperlipidemia

 No

TT

1

1

 

TA + AA

1.47(1.05–2.08)

0.090

0.92(0.66–1.32)

0.700

 Yes

TT

1

1

 

TA + AA

1.07(0.71–1.60)

0.740

1.39(0.94–2.05)

0.100

Hypertension

 No

TT

1

1

 

TA + AA

1.82(1.25–2.69)

0.002

1.28(0.91–1.80)

0.160

 Yes

TT

1

1

 

TA + AA

0.94(0.66–1.34)

0.750

0.92(0.59–1.34)

0.610

rs330910

Gender

 Male

AA

1

1

 

AT+TT

0.99(0.72–1.36)

0.960

0.91(0.66–1.27)

0.580

 Female

AA

1

1

 

AT+TT

2.07(1.32–3.26)

0.002

1.16(0.73–1.85)

0.530

Age, year

 ≤ 60

AA

1

1

 

AT+TT

1.33(0.94–1.87)

0.110

0.84(0.58–1.21)

0.350

 >  60

AA

1

1

 

AT+TT

1.24(0.84–1.84)

0.280

1.27(0.86–1.88)

0.220

BMI, kg/m2

 ≤ 24

AA

1

1

 

AT+TT

1.25(0.91–1.72)

0.170

1.04(0.75–1.43)

0.820

 >  24

AA

1

1

 

AT+TT

1.30(0.83–2.06)

0.260

0.91(0.57–1.46)

0.690

Smoking

 No

AA

1

1

 

AT+TT

1.37(0.97–1.92)

0.070

0.85(0.60–1.20)

0.360

 Yes

AA

1

1

 

AT+TT

1.16(0.77–1.74)

0.470

1.21(0.79–1.86)

0.390

Drinking

 No

AA

1

1

 

AT+TT

1.18(0.86–1.62)

0.300

1.06(0.76–1.48)

0.720

 Yes

AA

1

1

 

AT+TT

1.01(0.74–1.38)

0.960

0.82(0.52–1.30)

0.390

Hyperlipidemia

 No

AA

1

1

 

AT+TT

1.48(1.04–2.10)

0.030

0.81(0.56–1.16)

0.250

 Yes

AA

1

1

 

AT+TT

1.10(0.73–1.64)

0.650

1.30(0.87–1.93)

0.280

Hypertension

 No

AA

1

1

 

AT+TT

1.90(1.29–2.80)

0.001

1.05(0.74–1.49)

0.770

 Yes

AA

1

1

 

AT+TT

0.93(0.64–1.34)

0.680

0.94(0.62–1.42)

0.770

rs330915

Gender

 Male

AA

1

1

 

AT+TT

1.20(0.87–1.66)

0.270

1.22(0.87–1.70)

0.250

 Female

AA

1

1

 

AT+TT

1.12(0.71–1.77)

0.610

0.89(0.56–1.42)

0.630

Age, year

 ≤ 60

AA

1

1

 

AT+TT

1.20(0.87–1.66)

0.270

1.09(0.75–1.57)

0.670

 >  60

AA

1

 

1

 
 

AT+TT

1.30(0.88–1.94)

0.190

1.18(0.79–1.75)

0.410

BMI, kg/m2

 ≤ 24

AA

1

1

 

AT+TT

1.19(0.86–1.65)

0.290

1.20(0.86–1.66)

0.280

 >  24

AA

1

1

 

AT+TT

1.09(0.69–1.73)

0.700

0.98(0.61–1.57)

0.940

Smoking

 No

AA

1

1

 

AT+TT

1.31(0.93–1.84)

0.130

0.89(0.63–1.25)

0.510

 Yes

AA

1

1

 

AT+TT

0.97(0.64–1.48)

0.910

1.54(0.99–2.40)

0.060

Drinking

 No

AA

1

1

 

AT+TT

1.21(0.88–1.68)

0.240

1.09(0.78–1.53)

0.610

 Yes

AA

1

1

 

AT+TT

1.10(0.69–1.76)

0.680

1.04(0.66–1.65)

0.870

Hyperlipidemia

 No

AA

1

1

 

AT+TT

1.37(0.96–1.96)

0.070

1.03(0.72–1.48)

0.870

 Yes

AA

1

1

 

AT+TT

1.04(0.69–1.57)

0.860

1.31(0.87–1.97)

0.190

Hypertension

 No

AA

1

1

 

AT+TT

1.69(1.14–2.49)

0.008

1.24(0.87–1.77)

0.240

 Yes

AA

1

1

 

AT+TT

0.89(0.61–1.30)

0.530

1.00(0.66–1.51)

0.990

rs9949

Gender

 Male

GG

1

1

 

GA + AA

1.07(0.79–1.46)

0.660

1.13(0.82–1.55)

0.470

 Female

GG

1

1

 

GA + AA

1.74(1.12–2.71)

0.008

1.00(0.63–1.56)

0.980

Age, year

 ≤ 60

GG

1

1

 

GA + AA

1.28(0.91–1.80)

0.150

1.03(0.72–1.47)

0.960

 >  60

GG

1

1

 

GA + AA

1.24(0.85–1.82)

0.260

1.24(0.84–1.81)

0.280

BMI, kg/m2

 ≤ 24

GG

1

1

 

GA + AA

1.27(0.93–1.73)

0.960

1.25(0.91–1.71)

0.170

 >  24

GG

1

1

 

GA + AA

1.23(0.79–1.92)

0.37

0.82(0.52–1.31)

0.410

Smoking

 No

GG

1

1

 

GA + AA

1.34(0.96–1.86)

0.086

0.85(0.60–1.19)

0.330

 Yes

GG

1

1

 

GA + AA

1.15(0.77–1.71)

0.520

1.56(1.06–2.39)

0.009

Drinking

 No

GG

1

1

 

GA + AA

1.190.88–1.63)

0.260

1.06(0.77–1.46)

0.720

 Yes

GG

1

1

 

GA + AA

1.46(0.93–2.27)

0.100

1.03(0.66–1.61)

0.910

Hyperlipidemia

 No

GG

1

1

 

GA + AA

1.48(1.05–2.09)

0.030

0.93(0.66–1.33)

0.700

 Yes

GG

1

1

 

GA + AA

1.07(0.72–1.59)

0.740

1.39(0.94–2.05)

0.100

Hypertension

 No

GG

1

1

 

GA + AA

1.82(1.25–2.66)

0.002

1.28(0.91–1.80)

0.160

 Yes

GG

1

1

 

GA + AA

0.94(0.66–1.35)

0.750

0.91(0.61–1.35)

0.630

  1. P, the P value between patients and control, BMI body mass index. The P values for stratified analysis between the PPP1R3B polymorphisms on the risk of CAD/IS, were obtained from unconditional logistic regression, when one of the environmental factors was detected, the rest six factors in gender, age, BMI, smoking, alcohol consumption, hypertension and hyperlipidemia were adjusted
Back to article page

Nutrition & Metabolism

ISSN: 1743-7075

Contact us