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Table 5 Stratified analysis of the PPP1R3B genotypes and the risk of CAD or IS

From: Association between the PPP1R3B polymorphisms and serum lipid traits, the risk of coronary artery disease and ischemic stroke in a southern Chinese Han population

Factor Genotype OR(95%CI)CAD P CAD OR(95%CI)IS P IS
rs12785
Gender
 Male TT 1 1
  TA + AA 1.06(0.68–1.44) 0.830 1.15(0.80–1.56) 0.470
 Female TT 1 1
  TA + AA 1.76(1.13–2.73) 0.007 1.00(0.63–1.56) 0.970
Age, year
 ≤ 60 TT 1 1
  TA + AA 1.34(0.73–1.89) 0.280 1.03(0.70–1.50) 0.980
 >  60 TT 1 1
  TA + AA 1.24(0.85–1.82) 0.260 1.23(0.84–1.80) 0.280
BMI, kg/m2
 ≤ 24 TT 1 1
  TA + AA 1.27(0.93–1.74) 0.970 1.25(0.91–1.71) 0.170
 >  24 TT 1 1
  TA + AA 1.23(0.79–1.91) 0.370 0.80(0.49–1.32) 0.400
Smoking
 No TT 1 1
  TA + AA 1.34(0.97–1.87) 0.090 0.85(0.60–1.19) 0.330
 Yes TT 1 1
  TA + AA 1.15(0.78–1.71) 0.520 1.56(1.05–2.39) 0.009
Drinking
 No TT 1 1
  TA + AA 1.19(0.88–1.63) 0.270 1.06(0.77–1.45) 0.720
 Yes TT 1 1
  TA + AA 1.46(0.93–2.27) 0.100 1.03(0.66–1.61) 0.910
Hyperlipidemia
 No TT 1 1
  TA + AA 1.47(1.05–2.08) 0.090 0.92(0.66–1.32) 0.700
 Yes TT 1 1
  TA + AA 1.07(0.71–1.60) 0.740 1.39(0.94–2.05) 0.100
Hypertension
 No TT 1 1
  TA + AA 1.82(1.25–2.69) 0.002 1.28(0.91–1.80) 0.160
 Yes TT 1 1
  TA + AA 0.94(0.66–1.34) 0.750 0.92(0.59–1.34) 0.610
rs330910
Gender
 Male AA 1 1
  AT+TT 0.99(0.72–1.36) 0.960 0.91(0.66–1.27) 0.580
 Female AA 1 1
  AT+TT 2.07(1.32–3.26) 0.002 1.16(0.73–1.85) 0.530
Age, year
 ≤ 60 AA 1 1
  AT+TT 1.33(0.94–1.87) 0.110 0.84(0.58–1.21) 0.350
 >  60 AA 1 1
  AT+TT 1.24(0.84–1.84) 0.280 1.27(0.86–1.88) 0.220
BMI, kg/m2
 ≤ 24 AA 1 1
  AT+TT 1.25(0.91–1.72) 0.170 1.04(0.75–1.43) 0.820
 >  24 AA 1 1
  AT+TT 1.30(0.83–2.06) 0.260 0.91(0.57–1.46) 0.690
Smoking
 No AA 1 1
  AT+TT 1.37(0.97–1.92) 0.070 0.85(0.60–1.20) 0.360
 Yes AA 1 1
  AT+TT 1.16(0.77–1.74) 0.470 1.21(0.79–1.86) 0.390
Drinking
 No AA 1 1
  AT+TT 1.18(0.86–1.62) 0.300 1.06(0.76–1.48) 0.720
 Yes AA 1 1
  AT+TT 1.01(0.74–1.38) 0.960 0.82(0.52–1.30) 0.390
Hyperlipidemia
 No AA 1 1
  AT+TT 1.48(1.04–2.10) 0.030 0.81(0.56–1.16) 0.250
 Yes AA 1 1
  AT+TT 1.10(0.73–1.64) 0.650 1.30(0.87–1.93) 0.280
Hypertension
 No AA 1 1
  AT+TT 1.90(1.29–2.80) 0.001 1.05(0.74–1.49) 0.770
 Yes AA 1 1
  AT+TT 0.93(0.64–1.34) 0.680 0.94(0.62–1.42) 0.770
rs330915
Gender
 Male AA 1 1
  AT+TT 1.20(0.87–1.66) 0.270 1.22(0.87–1.70) 0.250
 Female AA 1 1
  AT+TT 1.12(0.71–1.77) 0.610 0.89(0.56–1.42) 0.630
Age, year
 ≤ 60 AA 1 1
  AT+TT 1.20(0.87–1.66) 0.270 1.09(0.75–1.57) 0.670
 >  60 AA 1   1  
  AT+TT 1.30(0.88–1.94) 0.190 1.18(0.79–1.75) 0.410
BMI, kg/m2
 ≤ 24 AA 1 1
  AT+TT 1.19(0.86–1.65) 0.290 1.20(0.86–1.66) 0.280
 >  24 AA 1 1
  AT+TT 1.09(0.69–1.73) 0.700 0.98(0.61–1.57) 0.940
Smoking
 No AA 1 1
  AT+TT 1.31(0.93–1.84) 0.130 0.89(0.63–1.25) 0.510
 Yes AA 1 1
  AT+TT 0.97(0.64–1.48) 0.910 1.54(0.99–2.40) 0.060
Drinking
 No AA 1 1
  AT+TT 1.21(0.88–1.68) 0.240 1.09(0.78–1.53) 0.610
 Yes AA 1 1
  AT+TT 1.10(0.69–1.76) 0.680 1.04(0.66–1.65) 0.870
Hyperlipidemia
 No AA 1 1
  AT+TT 1.37(0.96–1.96) 0.070 1.03(0.72–1.48) 0.870
 Yes AA 1 1
  AT+TT 1.04(0.69–1.57) 0.860 1.31(0.87–1.97) 0.190
Hypertension
 No AA 1 1
  AT+TT 1.69(1.14–2.49) 0.008 1.24(0.87–1.77) 0.240
 Yes AA 1 1
  AT+TT 0.89(0.61–1.30) 0.530 1.00(0.66–1.51) 0.990
rs9949
Gender
 Male GG 1 1
  GA + AA 1.07(0.79–1.46) 0.660 1.13(0.82–1.55) 0.470
 Female GG 1 1
  GA + AA 1.74(1.12–2.71) 0.008 1.00(0.63–1.56) 0.980
Age, year
 ≤ 60 GG 1 1
  GA + AA 1.28(0.91–1.80) 0.150 1.03(0.72–1.47) 0.960
 >  60 GG 1 1
  GA + AA 1.24(0.85–1.82) 0.260 1.24(0.84–1.81) 0.280
BMI, kg/m2
 ≤ 24 GG 1 1
  GA + AA 1.27(0.93–1.73) 0.960 1.25(0.91–1.71) 0.170
 >  24 GG 1 1
  GA + AA 1.23(0.79–1.92) 0.37 0.82(0.52–1.31) 0.410
Smoking
 No GG 1 1
  GA + AA 1.34(0.96–1.86) 0.086 0.85(0.60–1.19) 0.330
 Yes GG 1 1
  GA + AA 1.15(0.77–1.71) 0.520 1.56(1.06–2.39) 0.009
Drinking
 No GG 1 1
  GA + AA 1.190.88–1.63) 0.260 1.06(0.77–1.46) 0.720
 Yes GG 1 1
  GA + AA 1.46(0.93–2.27) 0.100 1.03(0.66–1.61) 0.910
Hyperlipidemia
 No GG 1 1
  GA + AA 1.48(1.05–2.09) 0.030 0.93(0.66–1.33) 0.700
 Yes GG 1 1
  GA + AA 1.07(0.72–1.59) 0.740 1.39(0.94–2.05) 0.100
Hypertension
 No GG 1 1
  GA + AA 1.82(1.25–2.66) 0.002 1.28(0.91–1.80) 0.160
 Yes GG 1 1
  GA + AA 0.94(0.66–1.35) 0.750 0.91(0.61–1.35) 0.630
  1. P, the P value between patients and control, BMI body mass index. The P values for stratified analysis between the PPP1R3B polymorphisms on the risk of CAD/IS, were obtained from unconditional logistic regression, when one of the environmental factors was detected, the rest six factors in gender, age, BMI, smoking, alcohol consumption, hypertension and hyperlipidemia were adjusted