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Table 7 The Papp values of CA across Caco-2 monolayers treated with various fatty acids and the TEER values (n = 5)

From: Medium-chain fatty acids decrease serum cholesterol via reduction of intestinal bile acid reabsorption in C57BL/6J mice

Group   C8:0 C10:0 C18:0 C18:1 Control
Condition
 Vehicle   + + + + +
 CA   + + + + +
 C8:0   +
 C10:0   +
 C18:0   +
 C18:1   +
Fatty acid concentration
 0 μmol/L P app e 1.16 ± 0.14
TEERf      622.80 ± 56.03
 50 μmol/L P app e 0.87 ± 0.06a,c,d 0.93 ± 0.13a,c 1.26 ± 0.19 1.06 ± 0.02
TEERf 669.80 ± 44.56 713.60 ± 87.06 653.40 ± 59.08 696.60 ± 116.57  
 100 μmol/L P app e 0.74 ± 0.03a,c,d 0.81 ± 0.06a,c,d 1.06 ± 0.21 1.1 ± 0.09
TEERf 710.60 ± 115.01 673.80 ± 60.20 628.40 ± 58.92 668.00 ± 124.00  
 200 μmol/L P app e 0.43 ± 0.07a,b,c,d 0.64 ± 0.04a,c,d 1.11 ± 0.16 1.02 ± 0.09
TEERf 707.00 ± 134.62 591.20 ± 47.56 651.00 ± 57.72 586.20 ± 53.60  
  1. aP < 0.05, versus control group
  2. bP < 0.05, versus C10:0
  3. cP < 0.05, versus C18:0 group
  4. dP < 0.05, versus C18:1 group
  5. ePapp of CA (AP → BL, cm/s × 10–6)
  6. fTEER values of Caco-2 monolayers (Ω·cm2)