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Table 2 Estimation of the standardized difference means of related indictors with CI 95% between the intervention and placebo groups

From: The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials

Variables Number of study Standardized mean difference CI 95% Heterogeneity
I2 (%) Q P-value
CRP Intervention group (after vs. before) 11 −0.88 −1.55, − 0.21 92.4 130.85 < 0.001
Placebo group (after vs. before) 11 −0.29 − 0.67, 0.09 80.3 50.87 < 0.001
Change intervention group vs. placebo group 13 −1.52 −2.25, −0.80 93.7 191.17 < 0.001
IL-6 Intervention group (after vs. before) 13 −0.99 −1.48, − 0.51 85.0 79.92 < 0.001
Placebo group (after vs. before) 13 0.03 −0.16, 0.22 17.8 14.59 0.264
Change intervention group vs. placebo group 15 −1.96 −2.60, − 1.32 90.6 149.58 < 0.001
TNF-α Intervention group (after vs. before) 10 −1.41 −2.03, −0.79 87.0 69.13 < 0.001
Placebo group (after vs. before) 10 −0.33 − 0.72, 0.05 71.4 31.50 < 0.001
Change intervention group vs. placebo group 10 −2.62 −3.70, −1.55 94.3 157.51 < 0.001
  1. IL-6 interlokin-6, CRP C-reactive protein, TNF-α tumor necrosis factor alpha