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Table 2 Fat mass and lean tissue distribution at baseline and after treatment

From: Effects of exenatide versus insulin glargine on body composition in overweight and obese T2DM patients: a randomized controlled trial

 

Exenatide

Insulin glargine

Estimated treatment difference, Exenatide vs Insulin glargine

Mean (95% CI)

P

Decreased value between two groups

Pre

Mean ± SE

Post

Mean ± SE

P

Pre

Mean ± SE

Post

Mean ± SE

P

Total fat mass (kg)

25.8 ± 1.0

23.7 ± 1.0

< 0.001

23.0 ± 1.1

23.0 ± 1.3

0.989

− 2.1 (− 3.2 to − 1.0)

0.001

Trunk fat (kg)

16.0 ± 0.6

14.7 ± 0.6

< 0.001

14.4 ± 0.9

14.4 ± 1.0

0.847

− 1.3 (− 2.0 to − 0.5)

0.001

Limb fat (kg)

8.6 ± 0.4

7.9 ± 0.4

< 0.001

7.5 ± 0.4

7.5 ± 0.4

0.825

− 0.8 (− 1.2 to 0.3)

0.005

Android fat (kg)

2.8 ± 0.1

2.5 ± 0.1

0.001

2.5 ± 0.2

2.4 ± 0.2

0.153

− 0.2 (− 0.4 to 0.1)

0.019

Gynoid fat (kg)

3.2 ± 0.2

3.0 ± 0.2

0.002

2.8 ± 0.2

2.8 ± 0.2

0.933

− 0.2 (− 0.3 to − 0.1)

0.018

Total fat mass (%)

32.4 ± 1.4

30.7 ± 1.4

< 0.001

31.0 ± 1.3

30.9 ± 1.5

0.619

− 1.5 (− 2.5 to − 0.5)

0.005

Trunk fat (%)

38.9 ± 1.4

36.5 ± 1.5

< 0.001

37.3 ± 1.6

36.9 ± 1.8

0.465

− 2.0 (− 3.5 to − 0.6)

0.006

Limb fat (%)

26.1 ± 1.5

25.0 ± 1.5

0.001

24.8 ± 1.3

24.8 ± 1.4

0.908

− 1.1 (− 1.9 to − 0.3)

0.010

Android fat (%)

42.0 ± 1.4

39.1 ± 1.5

< 0.001

40.5 ± 1.7

39.8 ± 1.0

0.278

− 2.2 (− 4.0 to − 0.4)

0.018

Gynoid fat (%)

28.4 ± 1.7

27.6 ± 1.6

0.046

26.5 ± 1.3

26.5 ± 1.4

0.973

− 0.8 (− 1.9 to 0.2)

0.128

Total lean tissue (kg)

52.0 ± 2.1

51.6 ± 2.2

0.278

48.4 ± 1.3

48.7 ± 1.4

0.445

− 0.7 (− 1.7 to 0.4)

0.216

Trunk lean tissue (kg)

24.6 ± 1.0

24.9 ± 1.0

0.123

23.2 ± 0.6

23.3 ± 0.6

0.600

0.2 (− 0.4 to 0.8)

0.460

Limb lean tissue (kg)

23.7 ± 1.1

23.0 ± 1.1

0.011

21.7 ± 0.8

21.8 ± 0.8

0.514

− 0.8 (− 1.4 to − 0.2)

0.019

Android lean tissue (kg)

3.8 ± 0.2

3.8 ± 0.2

0.750

3.5 ± 0.1

3.5 ± 0.1

0.863

0.0 (− 0.2 to 0.1)

0.013

Gynoid lean tissue (kg)

8.0 ± 0.3

7.9 ± 0.4

0.066

7.5 ± 0.2

7.5 ± 0.2

0.731

− 0.2 (− 0.4 to 0.0)

0.110

Total lean tissue (%)

64.3 ± 1.3

65.8 ± 1.3

< 0.001

65.5 ± 1.3

65.6 ± 1.5

0.693

1.4 (0.4 to 2.4)

0.007

Trunk lean tissue (%)

59.1 ± 1.3

61.4 ± 1.4

0.001

60.7 ± 1.6

61.0 ± 1.8

0.540

2.0 (0.5 to 3.5)

0.007

Limb lean tissue (%)

69.9 ± 1.5

70.8 ± 1.5

0.007

70.9 ± 1.2

71.0 ± 1.3

0.895

0.8 (0.0 to 1.7)

0.050

Android lean tissue (%)

57.2 ± 1.4

60.1 ± 1.5

< 0.001

58.7 ± 1.7

59.3 ± 2.0

0.323

2.2 (0.4 to 4.1)

0.017

Gynoid lean tissue (%)

69.1 ± 1.6

70.0 ± 1.6

0.049

70.8 ± 1.3

70.8 ± 1.4

0.994

0.8 (0.0 to 1.6)

0.019

  1. The percent fat mass was calculated by dividing local fat mass by weight of the same body regions; the percent lean tissue was calculated by dividing local lean mass by weight of the same body regions. P-values < 0.05 were considered indicative of statistically significant differences between the groups
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Nutrition & Metabolism

ISSN: 1743-7075

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