Fig. 1

ALA –treated OLETF rats had significantly lower final body weight, and glucose and insulin than the control OLETF rats. a Body weight was measured for 8 weeks of ALA treatment. b Fed plasma glucose, c water intake, d food intake was measured for 8 week of ALA treatment. The IP-GTT analyses were performed after 8 weeks of ALA treatment. e IP-GTT and f AUC of IP-GTT were assessed using blood glucose levels following an intraperitoneal injection of a 25% glucose solution (2 g/kg) after the rats had been fasted for 18 h. The g fasting blood glucose, h fasting insulin was measured at 8 weeks of ALA treatment. Data presented as mean ± SEM (LETO-C: n = 10; OLETF-C: n = 10; OLETF-ALA: n = 10). *: P < 0.05 vs. LETO-C. #: P < 0.05 vs. OLETF-C