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Table 2 Substrate oxidation and metabolic flexibility values during a hyperinsulinemic euglycemic clamp

From: Metabolic inflexibility in women with PCOS is similar to women with type 2 diabetes

  Basal (Fasted) State Insulin Stimulated State
  Normal BMI Obese T2DM PCOS Normal BMI Obese T2DM PCOS
RQ 0.84 ± 0.03a 0.82 ± 0.02a 0.83 ± 0.05a 0.76 ± 0.04b 0.98 ± 0.04a 0.95 ± 0.04a 0.88 ± 0.05b 0.81 ± 0.05c
CHO Ox (mg/kgFFM/min) 1.79 ± 0.56a 1.47 ± 0.34a 1.71 ± 0.88a 0.68 ± 0.72b 4.51 ± 0.80a 3.50 ± 0.76a 2.68 ± 0.87b 1.60 ± 0.94c
CHO Ox (mg/kgFFM + 17.7/min) 1.29 ± 0.38a 1.11 ± 0.27a 1.30 ± 0.69a 0.52 ± 0.54b 3.25 ± 0.53a 2.65 ± 0.57b 2.03 ± 0.68b 1.20 ± 0.69c
GDR/FFM (mg/kgFFM/min) 12.77 ± 3.55a 8.69 ± 2.04b 4.64 ± 1.14c 6.97 ± 3.33b
GDR/FFM + 17.7
(mg/kgFFM + 17.7/min)
9.22 ± 2.59a 6.58 ± 1.56b 3.53 ± 0.86c 5.19 ± 2.30b
NOGM (mg/kgFFM/min) 8.26 ± 3.30a 5.19 ± 1.77b 1.93 ± 1.04c 5.37 ± 3.02b
NOGM (mg/kgFFM + 17.7/min) 5.97 ± 2.42a 3.93 ± 1.35b 1.46 ± 0.78c 3.99 ± 2.14b
  1. Absolute values are expressed as mean ± standard deviation. Statistical analyses included age, race, and adiposity as covariates. Means from groups with no shared connecting letters are significantly different from one another. PCOS: polycystic ovary syndrome, T2DM: type 2 diabetes mellitus, RQ: respiratory quotient, CHO Ox: carbohydrate oxidation, GDR: glucose disposal rate, FFM: fat-free mass, NOGM: non-oxidative glucose metabolism